AMASTATIN

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Names

[ CAS No. ]:
67655-94-1

[ Name ]:
AMASTATIN

[Synonym ]:
amastatin,streptomyces species

Chemical & Physical Properties

[ Density]:
1.228g/cm3

[ Boiling Point ]:
795.1ºC at 760 mmHg

[ Molecular Formula ]:
C21H38N4O8

[ Molecular Weight ]:
474.54800

[ Flash Point ]:
434.7ºC

[ Exact Mass ]:
474.26900

[ PSA ]:
208.15000

[ LogP ]:
0.91940

[ Index of Refraction ]:
1.523

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CI9098850
CHEMICAL NAME :
L-Aspartic acid, N-(N-(3-amino-2-hydroxy-5-methyl-1-oxohexyl)-L-valyl) -L-valyl)-, (S-(R*,S*))-
CAS REGISTRY NUMBER :
67655-94-1
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C21-H38-N4-O8
MOLECULAR WEIGHT :
474.63

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>125 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 31,636,1978

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Boc-L-Valine
  • L-N-benzyloxycarbonylleucinal
  • benzyl ((1S,2S)-1-cyano-1-hydroxy-4-methylpentan-2-yl)carbamate
  • 3-amino-2-hydroxy-5-methylhexanoic acid
  • Cbz-D-Leu-OMe
  • L-Aspartic acid,N-[N-[(1,1-dimethylethoxy)carbonyl]-L-valyl]-, bis(phenylmethyl) ester (9CI)
  • Val-Val-Asp(OBzl)-OBzl
  • (2S,3R)-[3-[[(tert-Butyloxy)carbonyl]amino]-2-hydroxy-5-methylhexanoyl]-L-valyl-L-valyl-aspartic Acid Dibenzyl Ester

DownStream

Related Compounds

  • Amastatin · HCl
  • AMASTATIN HYDROCHLORIDE
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
  • N-[3-(Aminooxy)propyl]-N-butyl-1-butanamine