AMASTATIN

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Names

[ CAS No. ]:
67655-94-1

[ Name ]:
AMASTATIN

[Synonym ]:
amastatin,streptomyces species

Chemical & Physical Properties

[ Density]:
1.228g/cm3

[ Boiling Point ]:
795.1ºC at 760 mmHg

[ Molecular Formula ]:
C₂₁H₃₈N₄O₈

[ Molecular Weight ]:
474.54800

[ Flash Point ]:
434.7ºC

[ Exact Mass ]:
474.26900

[ PSA ]:
208.15000

[ LogP ]:
0.91940

[ Index of Refraction ]:
1.523

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CI9098850

CHEMICAL NAME :: L-Aspartic acid, N-(N-(3-amino-2-hydroxy-5-methyl-1-oxohexyl)-L-valyl) -L-valyl)-, (S-(R*,S*))-

CAS REGISTRY NUMBER :: 67655-94-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H38-N4-O8

MOLECULAR WEIGHT :: 474.63

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 31,636,1978

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Boc-L-Valine
L-N-benzyloxycarbonylleucinal
benzyl ((1S,2S)-1-cyano-1-hydroxy-4-methylpentan-2-yl)carbamate
3-amino-2-hydroxy-5-methylhexanoic acid
Cbz-D-Leu-OMe
L-Aspartic acid,N-[N-[(1,1-dimethylethoxy)carbonyl]-L-valyl]-, bis(phenylmethyl) ester (9CI)
Val-Val-Asp(OBzl)-OBzl
(2S,3R)-[3-[[(tert-Butyloxy)carbonyl]amino]-2-hydroxy-5-methylhexanoyl]-L-valyl-L-valyl-aspartic Acid Dibenzyl Ester