AMASTATIN

Modify Date: 2024-01-02 12:44:58

AMASTATIN structure	Common Name	AMASTATIN
	CAS Number	67655-94-1	Molecular Weight	474.54800
	Density	1.228g/cm3	Boiling Point	795.1ºC at 760 mmHg
	Molecular Formula	C₂₁H₃₈N₄O₈	Melting Point	N/A
	MSDS	N/A	Flash Point	434.7ºC

Use of AMASTATIN

Amastatin is a non-toxic inhibitor of aminopeptidase A (Ki = 1 μM) and leucine aminopeptidase. Also acts as a slow-binding, competitive inhibitor of aminopeptidase M. Does not inhibit aminopeptidase B, chymotrypsin, elastase, papain, pepsin, thermolysin, or trypsin.

Name	amastatin
Synonym	More Synonyms

Density	1.228g/cm3
Boiling Point	795.1ºC at 760 mmHg
Molecular Formula	C₂₁H₃₈N₄O₈
Molecular Weight	474.54800
Flash Point	434.7ºC
Exact Mass	474.26900
PSA	208.15000
LogP	0.91940
Index of Refraction	1.523

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CI9098850

CHEMICAL NAME :: L-Aspartic acid, N-(N-(3-amino-2-hydroxy-5-methyl-1-oxohexyl)-L-valyl) -L-valyl)-, (S-(R*,S*))-

CAS REGISTRY NUMBER :: 67655-94-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H38-N4-O8

MOLECULAR WEIGHT :: 474.63

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 31,636,1978

Hazard Codes	Xi

Precursor 8
CAS#:13734-41-3 Boc-L-Valine CAS#:70853-26-8 L-N-benzyloxyca... CAS#:63219-62-5 benzyl ((1S,2S)... CAS#:62023-30-7 3-amino-2-hydro...
CAS#:73397-22-5 Cbz-D-Leu-OMe CAS#:70853-19-9 L-Aspartic acid... CAS#:70853-23-5 Val-Val-Asp(OBz... CAS#:73397-34-9 (2S,3R)-[3-[[(t...
DownStream 0