Methyl phosphorodichloridate

Names

[ CAS No. ]:
677-24-7

[ Name ]:
Methyl phosphorodichloridate

[Synonym ]:
dichlorophosphoric acid methyl ester
Methyl phosphorodichloridate
dichlorophosphoryloxymethane
Phosphorodichloridic acid, methyl ester
EINECS 211-639-1
MFCD00002068

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
167.8±9.0 °C at 760 mmHg

[ Molecular Formula ]:
CH₃Cl₂O₂P

[ Molecular Weight ]:
148.913

[ Flash Point ]:
3.0±26.4 °C

[ Exact Mass ]:
147.924774

[ PSA ]:
36.11000

[ LogP ]:
0.71

[ Vapour Pressure ]:
2.2±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.422

[ Storage condition ]:
2-8°C

MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S27-S28-S36/37/39-S45

[ RIDADR ]:
UN 3265 8/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
8

Precursor & DownStream

Precursor

O-methyl O-phenyl S-propyl thiophosphate
Methanol
O,O,S-trimethyl phosphorothiate
O,O-Dimethyl O-phenyl phosphorothioate
PHENYL-PHOSPHONOTHIOIC ACID DIMETHYL ESTER

DownStream

Methyl paraoxon
2-methoxy-1,3,2λ5-dioxaphospholane 2-oxide
Dimethyl chlorophosphate
Diphosphoryl tetrachloride
2-methoxy-3-methyl-1,3,2λ5-oxazaphospholidine 2-oxide
Riboflavine phosphate
2-methoxy-4H-1,3,2λ5-benzodioxaphosphinine 2-oxide
DIPHENYL METHYL PHOSPHATE
N-(dimethylamino-methoxy-phosphoryl)-N-methyl-methanamine
1,1-dimethoxy-1-[methoxy(methyl)phosphoryl]ethane

Articles

Enzymatic release of antitumor ether lipids by specific phospholipase A2 activation of liposome-forming prodrugs.

J. Med. Chem. 47(7) , 1694-703, (2004)

An enzymatically activated liposome-based drug-delivery concept involving masked antitumor ether lipids (AELs) has been investigated. This concept takes advantage of the cytotoxic properties of AEL dr...

Synthesis of 8-(2"-hydroxyethoxy)adenosine-5',2"-phosphate derivative.

Nucleic Acids Symp. Ser. (17) , 61-3, (1986)

Reaction of 8-bromo-2',3'-O-isopropylidene-5'-O-(tetrahydropyran-2-yl) adenosine (Ib) with lithium 2-(tetrahydropyran-2-yloxy) ethoxide, followed by removal of the tetrahydropyran-2-yl groups, afforde...

Synthesis of oligosaccharides corresponding to Vibrio cholerae O139 polysaccharide structures containing dideoxy sugars and a cyclic phosphate.

Org. Biomol. Chem. 4(7) , 1236-41, (2006)

A spacer-equipped tetrasaccharide, p-aminocyclohexylethyl alpha-l-Colp-(1-->2)-beta-d-Galp-(1-->3)-[alpha-l-Colp-(1-->4)]-beta-D-GlcpNAc, containing a 4,6-cyclic phosphate in the galactose residue, ha...

S-Methyl phosphorodichloridate
methyl (3S)-3-hydroxy-5-methylhexanoate
methyl 4-bromo-5-hydroxyhexanoate
methyl-(6-morpholin-4-ylhexa-1,3,5-triynyl)-diphenylsilane
METHYL 5-OXO-3,5-DIHYDRO-2H-OXAZOLO[2,3-B]QUINAZOLINE-8-CARBOXYLATE
METHYL 7-NITRO-5-OXO-3,5-DIHYDRO-2H-OXAZOLO[2,3-B]QUINAZOLINE-8-CARBOXYLATE
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
3-(2,6-dichlorophenyl)-N-((6-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl)methyl)propanamide
N-((5-(furan-2-yl)pyridin-3-yl)methyl)-2-(1-methyl-1H-indol-3-yl)acetamide
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
N-(1-(benzo[b]thiophen-3-yl)propan-2-yl)-4-cyanobenzenesulfonamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde