phthalimidoacetyl chloride

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Names

[ CAS No. ]:
6780-38-7

[ Name ]:
phthalimidoacetyl chloride

[Synonym ]:
phthalimidoacetyl chloride
Phthalylglycyl chloride
2H-Isoindole-2-acetyl chloride, 1,3-dihydro-1,3-dioxo-
(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)acetyl chloride
MFCD00192872
EINECS 229-840-8

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
343.2±25.0 °C at 760 mmHg

[ Molecular Formula ]:
C10H6ClNO3

[ Molecular Weight ]:
223.613

[ Flash Point ]:
161.4±23.2 °C

[ Exact Mass ]:
223.003616

[ PSA ]:
54.45000

[ LogP ]:
1.94

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.615

[ Storage condition ]:
2~8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NR3394500
CHEMICAL NAME :
2H-Isoindole-2-acetyl chloride, 1,3-dihydro-1,3-dioxo-
CAS REGISTRY NUMBER :
6780-38-7
BEILSTEIN REFERENCE NO. :
0183000
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C10-H6-Cl-N-O3
MOLECULAR WEIGHT :
223.62

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JICSAH Journal of the Indian Chemical Society. (Indian Chemical Soc., 92, Acharya Prafulla Chandra Rd., Calcutta 700009, India) V.5- 1928- Volume(issue)/page/year: 67,852,1990

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R25;R34

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 2923

[ WGK Germany ]:
3

[ HS Code ]:
2925190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • N-Phthaloylglycine
  • 2-Methyl-2-propanyl bromoacetate
  • 3-Chloroaniline
  • Phthalic anhydride
  • N-carbethoxyphthalimide
  • Phosphorus pentachloride

DownStream

  • N-Acetonylphthalimide
  • Cyclo(Gly-L-Pro)
  • N-Phthaloylglycine
  • PHT-GLY-ONP
  • 2-(1,3-dioxoisoindol-2-yl)-N-phenyl-acetamide
  • ethyl 2-[[2-(1,3-dioxoisoindol-2-yl)acetyl]amino]acetate
  • ethenyl 2-(1,3-dioxoisoindol-2-yl)acetate
  • N-(2-Oxoethyl)phthalimide
  • Methyl phthalimidoacetate
  • 2-[[6-bromo-3-(4-hydroxyphenyl)-4-oxoquinazolin-2-yl]methyl]isoindole-1,3-dione

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Related Compounds

  • Pyrazinecarbonyl chloride, 6-chloro- (9CI)
  • YTTRIUM CHLORIDE HEXAHYDRATE
  • Ethanesulfonyl chloride
  • Cyclohexanecarbonyl chloride, 4-(1-methylpropyl)-, trans- (9CI)
  • Oxiranecarbonyl chloride, 2-methyl-3-phenyl-, trans- (9CI)
  • Benzeneethanesulfenyl chloride, alpha-chloro-beta-oxo- (9CI)
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 2-(2-Methoxy-phenoxy)-2-phenyl-ethylamine
  • Phenyl (3-(4-fluorophenyl)isoxazol-5-yl)carbamate
  • 2-Bromo-2-isocyanatoethyl acetate
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • (S)-1-(3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyrrolidin-1-yl)prop-2-en-1-one