GPRP

Suppliers

Names

[ CAS No. ]:
67869-62-9

[ Name ]:
GPRP

[Synonym ]:
glycine-proline-arginine-proline
FIBRINOLYSIS INHIBITNG FACTOR
LAUDANO-DOOLITTLE PEPTIDE
GPRP FIBRIN ANTIPOLYMERANT
GPRP
glycyl-L-prolyl-L-arginyl-L-prolin
MFCD00133378
glycyl-prolyl-arginyl-proline
FIBRINOLYSIS INHIBITING FACTOR
M.W. 425.49 C18H31N7O5

Chemical & Physical Properties

[ Density]:
1.55 g/cm3

[ Molecular Formula ]:
C18H31N7O5

[ Molecular Weight ]:
425.48300

[ Exact Mass ]:
425.23900

[ PSA ]:
194.94000

[ Index of Refraction ]:
1.691

[ Storage condition ]:
−20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • L-Proline, phenylmethylester
  • Z-Gly-Pro-Arg(NO2)-Pro-OBzl
  • H-Arg(NO2)-Pro-OBzl
  • Z(OMe)-Arg(NO2)-OH
  • L-Proline,N-[(phenylmethoxy)carbonyl]glycyl-, phenylmethyl ester (9CI)
  • Z-Gly-Pro-NHNH2
  • N-Boc-N'-nitro-L-arginine
  • H-Pro-OBzl.HCl
  • Boc-Arg(NO2)-Pro-OBzl

DownStream

Articles

Integrin-linked kinase regulates the rate of platelet activation and is essential for the formation of stable thrombi.

J. Thromb. Haemost. 12(8) , 1342-52, (2014)

Integrin-linked kinase (ILK) and its associated complex of proteins are involved in many cellular activation processes, including cell adhesion and integrin signaling. We have previously demonstrated ...

Platelet function tests, independent of platelet count, are associated with bleeding severity in ITP.

Blood 126 , 873-9, (2015)

Immune thrombocytopenia (ITP) patients with similarly low platelet counts differ in their tendency to bleed. To determine if differences in platelet function in ITP patients account for this variation...

Procoagulant platelets form an α-granule protein-covered "cap" on their surface that promotes their attachment to aggregates.

J. Biol. Chem. 288(41) , 29621-32, (2013)

Strongly activated "coated" platelets are characterized by increased phosphatidylserine (PS) surface expression, α-granule protein retention, and lack of active integrin αIIbβ3. To study how they are ...


More Articles

Related Compounds

  • GPRP acetate
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • N-(2-chlorobenzyl)-3-(phenylsulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide