1,4-BIS(TRICHLOROMETHYL)BENZENE

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Names

[ CAS No. ]:
68-36-0

[ Name ]:
1,4-BIS(TRICHLOROMETHYL)BENZENE

[Synonym ]:
EINECS 200-686-3
MFCD00000791
1,4-bis(trichloromethyl)benzene

Chemical & Physical Properties

[ Density]:
1.628 g/cm3

[ Boiling Point ]:
312 °C

[ Melting Point ]:
106-110 °C

[ Molecular Formula ]:
C8H4Cl6

[ Molecular Weight ]:
312.83500

[ Flash Point ]:
153ºC

[ Exact Mass ]:
309.84400

[ LogP ]:
5.34000

[ Index of Refraction ]:
1.584

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ZE4655000
CHEMICAL NAME :
p-Xylene, alpha,alpha,alpha,alpha',alpha',alpha'-hexachloro-
CAS REGISTRY NUMBER :
68-36-0
BEILSTEIN REFERENCE NO. :
2051282
LAST UPDATED :
199710
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C8-H4-Cl6
MOLECULAR WEIGHT :
312.82
WISWESSER LINE NOTATION :
GXGGR DXGGG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GNAMAP Gigiena Naselennykh Mest. Hygiene in Populated Places. (Izdatel'stvo Zdorov'ya, Kiev, USSR) V.7- 1967- Volume(issue)/page/year: 21,34,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2500 mg/kg/10D-I
TOXIC EFFECTS :
Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
REFERENCE :
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955- Volume(issue)/page/year: 32,107,1986 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2330 mg/kg
SEX/DURATION :
male 26 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
REFERENCE :
GNAMAP Gigiena Naselennykh Mest. Hygiene in Populated Places. (Izdatel'stvo Zdorov'ya, Kiev, USSR) V.7- 1967- Volume(issue)/page/year: 21,34,1982
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2330 mg/kg
SEX/DURATION :
female 26 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
GNAMAP Gigiena Naselennykh Mest. Hygiene in Populated Places. (Izdatel'stvo Zdorov'ya, Kiev, USSR) V.7- 1967- Volume(issue)/page/year: 21,34,1982 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 mg/m3;Skin JAN 1993

Safety Information

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S45-S36/37/39-S26

[ RTECS ]:
ZE4655000

[ HS Code ]:
2903999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • p-Xylene
  • 4-Methylbenzyl chloride
  • Formaldehyde
  • Toluene
  • 1,4-Bis(trifluoromethyl)benzene
  • Chlorine

DownStream

  • 2,5-BIS(TRIFLUOROMETHYL)-1,4-DICHLOROBENZENE
  • Benzoyl chloride,4-(trichloromethyl)-
  • 1,4-Bis(trifluoromethyl)benzene
  • Terephthalic acid dipropyl ester
  • p-Xylene, .alpha.,.alpha.,.alpha.,.alpha., .alpha.,.alpha.,2,5-octachloro-
  • 1,4-Benzenedicarboxylic acid dihexyl ester
  • Diisobutyl terephthalate
  • Diethyl terephthalate
  • 1-(CHLORODIFLUOROMETHYL)-4-(TRIFLUOROMETHYL)BENZENE
  • 1,4-bis-(Chlorodifluoromethyl)benzene

Customs

[ HS Code ]: 2903999090

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Related Compounds

  • 2-chloro-1,4-bis(trichloromethyl)benzene
  • 1,5-bis-trichloroacetyl-2,4-bis-trichloromethyl-benzene
  • p-Xylene, .alpha.,.alpha.,.alpha.,.alpha., .alpha.,.alpha.,2,5-octachloro-
  • Decachloro-p-xylene
  • 1,2,4,5-tetrachlorobenzene-d2
  • 1,4-bis[dichloro-[4-(trichloromethyl)phenyl]methyl]benzene
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 4-{1-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-methylpentanoyl]azetidin-3-yl}butanoic acid
  • 2-[N,3-dicyclopropyl-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2,2-difluoropropanamido]acetic acid
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 2-[(3S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-methylpentanamido]-3,3,3-trifluoro-2-methylpropanoic acid
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 1-(4-Bromophenyl)-2-(oxiran-2-yl)ethan-1-ol