(E/Z)-4-hydroxy Tamoxifen
Suppliers
Names
[ CAS No. ]:
68392-35-8
[ Name ]:
(E/Z)-4-hydroxy Tamoxifen
[Synonym ]:
Propiophenone,4'-[2-(diethylamino)ethoxy]-,hydrochloride
1-[4-(2-Diaethylamino-aethoxy)-phenyl]-propan-1-on,Hydrochlorid
1-[4-(2-diethylaminoethyloxy)phenyl]propan-1-one hydrochloride
4-hydroxytamoxifene
1-[4-(2-dimethylaminoethoxy)phenyl]-1-(4-hydroxyphenyl)-2-phenylbut-1-ene
(E,Z)-4-hydroxytamoxifen
1-[4-(2-diethylamino-ethoxy)-phenyl]-propan-1-one,hydrochloride
Chemical & Physical Properties
[ Density]:
1.092
[ Melting Point ]:
135-144°C
[ Molecular Formula ]:
C26H29NO2
[ Molecular Weight ]:
387.51400
[ Exact Mass ]:
387.22000
[ PSA ]:
32.70000
[ LogP ]:
5.70170
[ Appearance of Characters ]:
white to off-white
[ Storage condition ]:
Refrigerator
[ Water Solubility ]:
methanol: soluble10mg/mL
MSDS
Safety Information
[ Symbol ]:
GHS07, GHS08
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H312-H332-H361
[ Precautionary Statements ]:
P280
[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
63-20/21/22
[ Safety Phrases ]:
22-23-36
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
SL1210000
Precursor & DownStream
Precursor
DownStream
Articles
Breast Cancer Res. 17 , 26, (2015)
The emergence of hormone therapy resistance, despite continued expression of the estrogen receptor (ER), is a major challenge to curing breast cancer. Recent clinical studies suggest that epigenetic m...
BMC Cancer 14 , 853, (2014)
The RET tyrosine kinase receptor has emerged as a target in thyroid and endocrine resistant breast cancer. We previously reported the synthesis of kinase inhibitors with potent activity against RET. H...
PLoS ONE 9(10) , e111186, (2014)
Dynamins are fission proteins that mediate endocytic and exocytic membrane events and are pharmacological therapeutic targets. These studies investigate whether dynamin II regulates constitutive prote...