(E/Z)-4-hydroxy Tamoxifen
(E/Z)-4-hydroxy Tamoxifen structure
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Common Name | (E/Z)-4-hydroxy Tamoxifen | ||
|---|---|---|---|---|
| CAS Number | 68392-35-8 | Molecular Weight | 387.51400 | |
| Density | 1.092 | Boiling Point | N/A | |
| Molecular Formula | C26H29NO2 | Melting Point | 135-144°C | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
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Combined histone deacetylase inhibition and tamoxifen induces apoptosis in tamoxifen-resistant breast cancer models, by reversing Bcl-2 overexpression.
Breast Cancer Res. 17 , 26, (2015) The emergence of hormone therapy resistance, despite continued expression of the estrogen receptor (ER), is a major challenge to curing breast cancer. Recent clinical studies suggest that epigenetic modulation by histone deacetylase (HDAC) inhibitors reverses... |
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Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86.
BMC Cancer 14 , 853, (2014) The RET tyrosine kinase receptor has emerged as a target in thyroid and endocrine resistant breast cancer. We previously reported the synthesis of kinase inhibitors with potent activity against RET. Herein, we have further investigated the effect of the lead ... |
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Pharmacological inhibition of dynamin II reduces constitutive protein secretion from primary human macrophages.
PLoS ONE 9(10) , e111186, (2014) Dynamins are fission proteins that mediate endocytic and exocytic membrane events and are pharmacological therapeutic targets. These studies investigate whether dynamin II regulates constitutive protein secretion and show for the first time that pharmacologic... |
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Loss of CARD9-mediated innate activation attenuates severe influenza pneumonia without compromising host viral immunity.
Sci. Rep. 5 , 17577, (2015) Influenza virus (IFV) infection is a common cause of severe viral pneumonia associated with acute respiratory distress syndrome (ARDS), which is difficult to control with general immunosuppressive therapy including corticosteroids due to the unfavorable effec... |
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Suppression of BRCA1 sensitizes cells to proteasome inhibitors.
Cell Death Dis. 5 , e1580, (2014) BRCA1 is a multifunctional protein best known for its role in DNA repair and association with breast and ovarian cancers. To uncover novel biologically significant molecular functions of BRCA1, we tested a panel of 198 approved and experimental drugs to inhib... |
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PTEN mediates Notch-dependent stalk cell arrest in angiogenesis.
Nat. Commun. 6 , 7935, (2015) Coordinated activity of VEGF and Notch signals guides the endothelial cell (EC) specification into tip and stalk cells during angiogenesis. Notch activation in stalk cells leads to proliferation arrest via an unknown mechanism. By using gain- and loss-of-func... |
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The LIM homeodomain factor Lhx2 is required for hypothalamic tanycyte specification and differentiation.
J. Neurosci. 34(50) , 16809-20, (2014) Hypothalamic tanycytes, a radial glial-like ependymal cell population that expresses numerous genes selectively enriched in embryonic hypothalamic progenitors and adult neural stem cells, have recently been observed to serve as a source of adult-born neurons ... |
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Ultra-high performance liquid chromatography tandem mass spectrometric method for the determination of tamoxifen, N-desmethyltamoxifen, 4-hydroxytamoxifen and endoxifen in dried blood spots--development, validation and clinical application during breast cancer adjuvant therapy.
Talanta 132 , 775-84, (2014) A LC-MSMS method for the simultaneous determination of tamoxifen, N-desmethyltamoxifen, 4-hydroxytamoxifen and endoxifen in dried blood spots samples was developed and validated. The method employs an ultrasound-assisted liquid extraction and a reversed phase... |
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Selectivity of natural, synthetic and environmental estrogens for zebrafish estrogen receptors.
Toxicol. Appl. Pharmacol. 280(1) , 60-9, (2014) Zebrafish, Danio rerio, is increasingly used as an animal model to study the effects of pharmaceuticals and environmental estrogens. As most of these estrogens have only been tested on human estrogen receptors (ERs), it is necessary to measure their effects o... |
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Arteries are formed by vein-derived endothelial tip cells.
Nat. Commun. 5 , 5758, (2014) Tissue vascularization entails the formation of a blood vessel plexus, which remodels into arteries and veins. Here we show, by using time-lapse imaging of zebrafish fin regeneration and genetic lineage tracing of endothelial cells in the mouse retina, that v... |