N-Nitroso-N-methylurea

Names

[ CAS No. ]:
684-93-5

[ Name ]:
N-Nitroso-N-methylurea

[Synonym ]:
EINECS 211-678-4
1-Methyl-1-nitrosourea
Urea, N-methyl-N-nitroso-
N-nitroso-N-methylurea
MFCD00014794

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
164.3±23.0 °C at 760 mmHg

[ Melting Point ]:
119-124°C

[ Molecular Formula ]:
C₂H₅N₃O₂

[ Molecular Weight ]:
103.080

[ Flash Point ]:
53.1±22.6 °C

[ Exact Mass ]:
103.038177

[ PSA ]:
75.76000

[ LogP ]:
-0.03

[ Vapour Pressure ]:
2.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.545

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable. Flammable. Incompatible with strong oxidizing agents, strong bases, strong acids.

MSDS

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H228-H301-H350-H360

[ Precautionary Statements ]:
P201-P210-P301 + P310-P308 + P313

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P2 (EN 143) respirator cartridges;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
F:Flammable

[ Risk Phrases ]:
R45;R46;R61;R11;R25

[ Safety Phrases ]:
S53-S45-S24/25-S22

[ RIDADR ]:
UN 1325 4.1/PG 2

[ WGK Germany ]:
-

[ RTECS ]:
YT7875000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1-Methylurea
Acetamide,N-[(methylamino)carbonyl]-
METHYLNITROSOCYANAMIDE
Methylamine hydrochloride
Urea
Potassium cyanate
Water
Urea, methyl-, mononitrate

DownStream

Methanol
methylamine
1-Methylurea
BENZYLUREA
1,1-DIMETHYLUREA
AMMONIUMCYANATE
Urea
2-amino-6-chloro benzoicacid methylester
Hydrazinecarboxamide,1-methyl-
Guaiacol

Articles

A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens.

Arch. Toxicol. 89 , 2413-27, (2015)

Alternative methods to detect non-genotoxic carcinogens are urgently needed, as this class of carcinogens goes undetected in the current testing strategy for carcinogenicity under REACH. A complicatin...

Optimal dose selection of N-methyl-N-nitrosourea for the rat comet assay to evaluate DNA damage in organs with different susceptibility to cytotoxicity.

Mutat. Res. Genet. Toxicol. Environ. Mutagen. 786-788 , 129-36, (2015)

The in vivo rodent alkaline comet assay (comet assay) is a promising technique to evaluate DNA damage in vivo. However, there is no agreement on a method to evaluate DNA damage in organs where cytotox...

Multiple programmed cell death pathways are involved in N-methyl-N-nitrosourea-induced photoreceptor degeneration.

Graefes Arch. Clin. Exp. Ophthalmol. 253 , 721-31, (2015)

To identify programmed cell death (PCD) pathways involved in N-methyl-N-nitrosourea (MNU)-induced photoreceptor (PR) degeneration.Adult C57BL/6 mice received a single MNU i.p. injection (60 mg/kg body...