N6-Etheno 2'-deoxyadenosine

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Names

[ CAS No. ]:
68498-25-9

[ Name ]:
N6-Etheno 2'-deoxyadenosine

[Synonym ]:
1,N6-Etheno-2'-deoxyadenosine
1,N6-ETHENO-2'-DEOXY-ADENOSINE

Chemical & Physical Properties

[ Density]:
1.85 g/cm3

[ Molecular Formula ]:
C12H13N5O3

[ Molecular Weight ]:
275.26300

[ Exact Mass ]:
275.10200

[ PSA ]:
97.70000

[ Index of Refraction ]:
1.876

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Chloroacetaldehyde
  • 2'-Deoxyadenosine
  • 3'-O,5'-O-Dibenzoyl-2'-deoxyadenosine
  • Linoleic acid
  • N6-benzoyl-2'-Deoxyadenosine
  • 1,N6-ETHENOADENINE
  • 2'-Deoxycytidine monohydrate

DownStream

  • 7H-Imidazo[4,5-d]-1,2,3-triazin-4-amine,7-(2-deoxy-b-D-erythro-pentofuranosyl)-
  • 1,N6-ETHENOADENINE
  • 9-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,3,4,7,9-pentazabicyclo[4.3.0]nona-3,7,10-trien-5-one

Articles

In vitro synthesis of 1,N6-etheno-2'-deoxyadenosine and 1,N2-etheno-2'-deoxyguanosine by 2,4-dinitrophenol and 1,3-dinitropyrene in presence of a bacterial nitroreductase.

Environ. Toxicol. 22(2) , 222-7, (2007)

The formation of covalent nitro-PAH DNA adducts and nitro-PAH mediated oxidative lesions are two possible mechanisms for the initiation of nitro-PAH carcinogenesis. Sixty-minute incubation of 1,3-dini...

Urinary level of 1,N(6) -ethenodeoxyadenosine, a marker of oxidative stress, is associated with salt excretion and omega 6-polyunsaturated fatty acid intake in postmenopausal Japanese women.

Int. J. Cancer 100(1) , 71-5, (2002)

Excretion of 1,N(6)-ethenodeoxyadenosine (epsilon dA), a marker for lipid peroxidation (LPO)-derived DNA damage was analyzed in urine of nonsmoking postmenopausal women participating in a dietary inte...

Urinary excretion of epsilondA is not predictive of cancer development: a prospective nested case-control study.

Free Radic. Res. 39(1) , 51-3, (2005)

Human biomonitoring of the lipid peroxidation DNA modification 1,N6-ethenodeoxyadenosine (epsilondA) excreted into urine is thought to be a potential marker for oxidative stress-related DNA damage and...


More Articles

Related Compounds

  • 1,N6-ETHENO-2'-DEOXY-ADENOSINE 5'-MONOPHOSPHATE SODIUM SALT
  • 1,N(6)-etheno-2'-deoxyadenosine 5'-triphosphate
  • N6--Benzoyl-2'-deoxyadenosine hydrate
  • N6-benzoyl-2'-Deoxyadenosine
  • N6-Benzoyl-2'-deoxyadenosine
  • N6-hydroxy-2'-deoxyadenosine