7-Deazaadenosine(Tubercidin)
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Names
[ CAS No. ]:
69-33-0
[ Name ]:
7-Deazaadenosine(Tubercidin)
[Synonym ]:
EINECS 200-703-4
Tubercidine
sparsomycina
7H-pyrrolo[2,3-d]pyrimidin-4-amine, 7-β-D-ribofuranosyl-
MFCD00056012
TUBERCIDIN
4-amino-7-(D-ribofuranosyl)-7H-pyrrolo{2,3-d}pyrimidine
7-Deazaadenosine
Sparsomycine A
Chemical & Physical Properties
[ Density]:
1.9±0.1 g/cm3
[ Boiling Point ]:
648.8±55.0 °C at 760 mmHg
[ Melting Point ]:
247-248 °C (decomp)
[ Molecular Formula ]:
C11H14N4O4
[ Molecular Weight ]:
266.253
[ Flash Point ]:
346.2±31.5 °C
[ Exact Mass ]:
266.101501
[ PSA ]:
126.65000
[ LogP ]:
-0.12
[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C
[ Index of Refraction ]:
1.834
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UY8870000
- CHEMICAL NAME :
- 7H-Pyrrolo(2,3-d)pyrimidine, 4-amino-7-beta-D-ribofuranosyl-
- CAS REGISTRY NUMBER :
- 69-33-0
- BEILSTEIN REFERENCE NO. :
- 0038498
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 13
- MOLECULAR FORMULA :
- C11-H14-N4-O4
- MOLECULAR WEIGHT :
- 266.29
- WISWESSER LINE NOTATION :
- T56 BN GN INJ FZ I- BT5OTJ CQ DQ E1Q
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 16 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - pleural effusion Gastrointestinal - other changes Lungs, Thorax, or Respiration - pleural effusion
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - pleural effusion Gastrointestinal - peritonitis Liver - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 28320 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 45 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 48 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 48 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- Dominant lethal test
MUTATION DATA
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Rodent - rabbit Kidney
- DOSE/DURATION :
- 30 ug/L
- REFERENCE :
- BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 38,1771,1989
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H300
[ Precautionary Statements ]:
P264-P301 + P310
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
[ Hazard Codes ]:
T+: Very toxic;
[ Risk Phrases ]:
R28
[ Safety Phrases ]:
S45;S36/S37/S39
[ RIDADR ]:
UN 3462 6.1/PG 2
[ WGK Germany ]:
3
[ RTECS ]:
UY8870000
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1(a)
[ HS Code ]:
29419090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
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