D-Mannitol

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Names

[ CAS No. ]:
69-65-8

[ Name ]:
D-Mannitol

[Synonym ]:
Mannit p
MFCD00064287
Cytosine API
4-aminopyrimidin-2-one
D-Mannitol
EINECS 200-711-8
(2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol
Mannitol
Cordycepate
(2R,3R,4R,5R)-Hexan-1,2,3,4,5,6-hexol
Cytosine (100 mg)
[3H]-Cytosine
Osmitrol
manicol
[3H]-D-(-)-Mannitol
D-Mannitol (JP15)
Cyt
[14C]-D-(-)-Mannitol
Mannitol (USP)
Maniton S
Mushroom sugar
(2R,3R,4R,5R)-1,2,3,4,5,6-Hexanehexol
Osmitrol (TN)
Cytosin
Cytosinimine

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
494.9±0.0 °C at 760 mmHg

[ Melting Point ]:
167-170ºC

[ Molecular Formula ]:
C₆H₁₄O₆

[ Molecular Weight ]:
182.172

[ Flash Point ]:
292.5±23.3 °C

[ Exact Mass ]:
182.079041

[ PSA ]:
121.38000

[ LogP ]:
-4.67

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.597

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OP2060000

CHEMICAL NAME :: Mannitol, D-

CAS REGISTRY NUMBER :: 69-65-8

BEILSTEIN REFERENCE NO. :: 1721898

LAST UPDATED :: 199701

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C6-H14-O6

MOLECULAR WEIGHT :: 182.20

WISWESSER LINE NOTATION :: Q1YQYQ 2 -BBAA -D

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 17143 mg/kg/2D-C

TOXIC EFFECTS :: Vascular - BP elevation not characterized in autonomic section Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9690 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 22 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - ulceration or bleeding from small intestine

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 14 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7470 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 50 mmol/L

REFERENCE :: PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 79,1171,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4308 No. of Facilities: 1555 (estimated) No. of Industries: 14 No. of Occupations: 31 No. of Employees: 41268 (estimated) No. of Female Employees: 28689 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
OP2060000

[ HS Code ]:
2905430000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

sucrose
D-Mannose
Cellulose microcrystalline
Cellobiose
D-(+)-Glucose
β-D-Glucopyranose
Fructose
D-fructofuranose
D-glucopyranose

DownStream

D-Mannitol,1,3:4,6-di-O-methylene-
1,3:2,5:4,6-tri-o-methylene-d-mannitol
hexane-1,2,5-triol
3,4-o-isopropylidene-d-mannitol
Sucralose
1,5-Anhydro-D-mannitol
1,4:3,6-Dianhydrohexitol
1,4-Anhydro-D-mannitol
2,5-Anhydro-D-glucitol
2,5-anhydromannitol

Customs

[ HS Code ]: 2905430000

[ Summary ]:
HS:2905430000 (2r,3r,4r,5r)-hexane-1,2,3,4,5,6-hexaol VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB MFN tariff:8.0% General tariff:30.0%

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