D-Mannitol

Modify Date: 2024-01-02 13:58:30

D-Mannitol Structure
D-Mannitol structure
 Common Name D-Mannitol
CAS Number 69-65-8 Molecular Weight 182.172
Density 1.6±0.1 g/cm3 Boiling Point 494.9±0.0 °C at 760 mmHg
Molecular Formula C6H14O6 Melting Point 167-170ºC
MSDS Chinese USA Flash Point 292.5±23.3 °C

 Use of D-Mannitol


D-Mannitol is an osmotic diuretic agent and a weak renal vasodilator.Target: OthersD(-)Mannitol is a sugar alcohol that can be used as an inert osmotic control substance. The uptake and phosphorylation of d-mannitol is catalyzed by the mannitol-specific phosphoenolpyruvate-dependent phosphotransferase systems (PTS). Mannitol can interact with neutrophils and monocytes. Experiments have shown that it is able to decrease neutrophil apoptosis in vitro. The compound has been used in studies as a stimulator of cecal microbial growth and cellulolytic activity in rabbits. It has been observed that mannitol can lower the fat digestibility and body fat accumulation in both normal and cecectomized rats, as well as upregulate monocyte HLA-DR, monocyte and neutrophil CD11b. Studies show that the mannitol operon is repressed by the transcription factor, mannitol operon repressor (MtlR) in Escherichia coli [1-3].

 Names

Name D-mannitol
Synonym More Synonyms

 D-Mannitol Biological Activity

Description D-Mannitol is an osmotic diuretic agent and a weak renal vasodilator.Target: OthersD(-)Mannitol is a sugar alcohol that can be used as an inert osmotic control substance. The uptake and phosphorylation of d-mannitol is catalyzed by the mannitol-specific phosphoenolpyruvate-dependent phosphotransferase systems (PTS). Mannitol can interact with neutrophils and monocytes. Experiments have shown that it is able to decrease neutrophil apoptosis in vitro. The compound has been used in studies as a stimulator of cecal microbial growth and cellulolytic activity in rabbits. It has been observed that mannitol can lower the fat digestibility and body fat accumulation in both normal and cecectomized rats, as well as upregulate monocyte HLA-DR, monocyte and neutrophil CD11b. Studies show that the mannitol operon is repressed by the transcription factor, mannitol operon repressor (MtlR) in Escherichia coli [1-3].
Related Catalog
Target

Human Endogenous Metabolite
References

[1]. Tan, K., et al., The mannitol operon repressor MtlR belongs to a new class of transcription regulators in bacteria. J Biol Chem, 2009. 284(52): p. 36670-9.

[2]. Nishiyama, A., et al., Mannitol lowers fat digestibility and body fat accumulation in both normal and cecectomized rats. J Nutr Sci Vitaminol (Tokyo), 2009. 55(3): p. 242-51.

[3]. Hanieh, H. and E. Sakaguchi, Effect of D-mannitol on feed digestion and cecotrophic system in rabbits. Anim Sci J, 2009. 80(2): p. 157-62.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 494.9±0.0 °C at 760 mmHg
Melting Point 167-170ºC
Molecular Formula C6H14O6
Molecular Weight 182.172
Flash Point 292.5±23.3 °C
Exact Mass 182.079041
PSA 121.38000
LogP -4.67
Vapour Pressure 0.0±2.8 mmHg at 25°C
Index of Refraction 1.597

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OP2060000
CHEMICAL NAME :
Mannitol, D-
CAS REGISTRY NUMBER :
69-65-8
BEILSTEIN REFERENCE NO. :
1721898
LAST UPDATED :
199701
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C6-H14-O6
MOLECULAR WEIGHT :
182.20
WISWESSER LINE NOTATION :
Q1YQYQ 2 -BBAA -D

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
17143 mg/kg/2D-C
TOXIC EFFECTS :
Vascular - BP elevation not characterized in autonomic section Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
13500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
9690 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
22 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Gastrointestinal - ulceration or bleeding from small intestine
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
14 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7470 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
50 mmol/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 79,1171,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4308 No. of Facilities: 1555 (estimated) No. of Industries: 14 No. of Occupations: 31 No. of Employees: 41268 (estimated) No. of Female Employees: 28689 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS OP2060000
HS Code 2905430000

 Synthetic Route

 Customs

HS Code 2905430000
Summary HS:2905430000 (2r,3r,4r,5r)-hexane-1,2,3,4,5,6-hexaol VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB MFN tariff:8.0% General tariff:30.0%

 Articles573

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 Synonyms

Mannit p
MFCD00064287
Cytosine API
4-aminopyrimidin-2-one
D-Mannitol
EINECS 200-711-8
(2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol
Mannitol
Cordycepate
(2R,3R,4R,5R)-Hexan-1,2,3,4,5,6-hexol
Cytosine (100 mg)
[3H]-Cytosine
Osmitrol
manicol
[3H]-D-(-)-Mannitol
D-Mannitol (JP15)
Cyt
[14C]-D-(-)-Mannitol
Mannitol (USP)
Maniton S
Mushroom sugar
(2R,3R,4R,5R)-1,2,3,4,5,6-Hexanehexol
Osmitrol (TN)
Cytosin
Cytosinimine
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Price: $66/10mM*1mLinWater

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Related Compounds: More...
D-Mannitol-d2
2649096-16-0
D-Mannitol-13C
132202-29-0
D-Mannitol-13C6
287112-34-9
D-Mannitol-1-13C
70849-29-5
D-Mannitol-2-13C
287100-69-0
D-Mannitol-13C,d2
1217463-58-5
D-Mannitol-acetat
642-00-2
1-Deoxy-d-mannitol
87-96-7
1-deoxy-D-mannitol
60965-81-3
Chemsrc provides D-Mannitol(CAS#:69-65-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of D-Mannitol are included as well.>> amp version: D-Mannitol

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