5-Hydroxydiclofenac

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Names

[ CAS No. ]:
69002-84-2

[ Name ]:
5-Hydroxydiclofenac

[Synonym ]:
5-Hydroxydiclofenac
Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-5-hydroxy-
5-OH DCF
{2-[(2,6-Dichlorophenyl)amino]-5-hydroxyphenyl}acetic acid
2-[2-(2,6-dichloroanilino)-5-hydroxyphenyl]acetic acid
5-hydroxydiclophenac

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
444.8±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C14H11Cl2NO3

[ Molecular Weight ]:
312.148

[ Flash Point ]:
222.8±28.7 °C

[ Exact Mass ]:
311.011597

[ PSA ]:
69.56000

[ LogP ]:
3.91

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.690

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AG6308000
CHEMICAL NAME :
Acetic acid, (2-(2,6-dichloroanilino)-5-hydroxyphenyl)-
CAS REGISTRY NUMBER :
69002-84-2
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C14-H11-Cl2-N-O3
MOLECULAR WEIGHT :
312.16

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1430 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SJRHAT Scandinavian Journal of Rheumatology. (Almqvist & Wiksell, POB 45150, S-10430 Stockholm, Sweden) V.1- 1972- Volume(issue)/page/year: (Suppl 22),5,1978

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335-H410

[ Precautionary Statements ]:
P273-P280-P301 + P312 + P330-P337 + P313-P391-P501

[ RIDADR ]:
UN 3077 9 / PGIII

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Diclofenac
  • 2-[2-(2,6-dichloroanilino)-5-hydroxyphenyl]-N,N-dimethylacetamide
  • Diclofenac sodium
  • 1-(2,6-dichlorophenyl)-5-hydroxy-3H-indol-2-one
  • 2,6-Dichloro-N-(4-Methoxyphenyl) Benzenamine
  • 2-(3-methoxyphenyl)-N,N-dimethylacetamide
  • 2-(2-iodo-5-methoxyphenyl)-N,N-dimethylacetamide
  • 2-[2-(2,6-dichloroanilino)-5-methoxyphenyl]-N,N-dimethylacetamide
  • 4-Nitrophenol

DownStream

  • 1-(2,6-dichlorophenyl)-5-hydroxy-3H-indol-2-one

Related Compounds

  • 5-[(4-phenylphenyl)methylidene]imidazolidine-2,4-dione
  • 5-(3-formyl-2-hydroxyphenyl)benzene-1,3-dicarboxylic acid
  • 5,8-difluoro-4-methyl-1,2,3,4-tetrahydronaphthalen-1-ol
  • 5-(p-Toluenesulfonate)-2,3-O-isopropylidene-2-C-methyl-D-ribonic-gamma-lactone
  • 5-(oxiran-2-ylmethoxy)-2,3,4,9-tetrahydro-1H-carbazole
  • 5-(2,4-difluorophenyl)-2-hydroxy-3-sulfooxybenzoic acid
  • 2,2-Dimethylhept-3-enoic acid
  • 1-Benzyl-4-(1-methyl-1H-pyrazol-3-yl)pyrrolidine-3-carboxylic acid
  • (8-Methyl-1,7-dioxaspiro[4.4]nonan-2-yl)methanamine
  • {8-Methyl-1,7-dioxaspiro[4.4]nonan-2-yl}methanol
  • {Bicyclo[4.1.0]heptan-3-yl}methanethiol
  • 5-Chloro-1,2,3,6-tetrahydropyridine-1-carbonyl chloride
  • 3-(3-Bromopropyl)thiolane
  • Methyl 2-amino-4-fluoro-5-nitrobenzoate
  • Methyl 4-aminocinnoline-3-carboxylate
  • (3S)-N-(3-Hydroxycyclohexyl)pyrrolidine-3-carboxamide
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