1-Cyanocyclopropanecarboxylic acid

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
325.0±25.0 °C at 760 mmHg

[ Melting Point ]:
140 °C(lit.)

[ Molecular Formula ]:
C₅H₅NO₂

[ Molecular Weight ]:
111.099

[ Flash Point ]:
150.3±23.2 °C

[ Exact Mass ]:
111.032028

[ PSA ]:
61.09000

[ LogP ]:
-0.97

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.519

Click to get detail MSDS

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H312-H314-H332

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R20/21/22;R34

[ Safety Phrases ]:
S26-S27-S36/37/39-S45-S25

[ RIDADR ]:
UN 3261 8/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2926909090

Click to get detail synthetic route

Precursor

DownStream

[ HS Code ]: 2926909090

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells.

J. Med. Chem. 54(10) , 3524-48, (2011)

Sphingosine 1-phosphate (S1P) is a bioactive lipid that has been identified as an accelerant of cancer progression. The sphingosine kinases (SphKs) are the sole producers of S1P, and thus, SphK inhibi...

Substituted cyclopropanes. 5. 1-Cyanocyclopropanecarboxylic acid. Jones PG and Schrumpf G.

Acta Crystallogr. C Struct. Chem. 43(8) , 1576-79, (1987)

Homoconjugate Addition of Nucleophiles to Cyclopropane-1, 1-Dicarboxylate Derivatives: 2-Oxo-1-Phenyl-3-Pyrrolidinecarboxylic Acid. Singh RK and Danishefsky S.

Organic Synth. , 66-66

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