CRT0044876

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
520.8±30.0 °C at 760 mmHg

[ Melting Point ]:
260-261 °C

[ Molecular Formula ]:
C₉H₆N₂O₄

[ Molecular Weight ]:
206.155

[ Flash Point ]:
268.8±24.6 °C

[ Exact Mass ]:
206.032761

[ PSA ]:
98.91000

[ LogP ]:
2.80

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.761

[ Storage condition ]:
room temp

Click to get detail MSDS

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H319-H334

[ Precautionary Statements ]:
P261-P305 + P351 + P338-P342 + P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R21/22;R36/37/38

[ Safety Phrases ]:
S36/37/39-S26-S22

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Click to get detail synthetic route

Precursor

DownStream

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy.

Nucleic Acids Res. 42(5) , 3089-103, (2014)

Base damage and topoisomerase I (Top1)-linked DNA breaks are abundant forms of endogenous DNA breakage, contributing to hereditary ataxia and underlying the cytotoxicity of a wide range of anti-cancer...

APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination.

J. Exp. Med. 204 , 3017-3026

Antibody class switch recombination (CSR) occurs by an intrachromosomal deletion requiring generation of double-stranded breaks (DSBs) in switch-region DNA. The initial steps in DSB formation have bee...

A novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase beta.

Nucleic Acids Res. 39 , 3156-65, (2011)

DNA repair is required to maintain genome stability in stem cells and early embryos. At critical junctures, oxidative damage to DNA requires the base excision repair (BER) pathway. Since early zebrafi...

More Articles