mephenoxalone
Suppliers
Names
[ CAS No. ]:
70-07-5
[ Name ]:
mephenoxalone
[Synonym ]:
Control-OM
5-[(2-Methoxyphenoxy)methyl]-1,3-oxazolidin-2-one
2-Oxazolidinone, 5-[(2-methoxyphenoxy)methyl]-
Mefenoxalona
Mefenoxalone
EINECS 200-723-3
mephenoxalone
5-({[2-(methyloxy)phenyl]oxy}methyl)-1,3-oxazolidin-2-one
Moderamin
Methoxydone
5-[(2-Methoxyphenoxy)methyl]-2-oxazolidinone
Methoxydon
Dorsiflex
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
440.0±18.0 °C at 760 mmHg
[ Molecular Formula ]:
C11H13NO4
[ Molecular Weight ]:
223.23
[ Flash Point ]:
219.9±21.2 °C
[ Exact Mass ]:
223.084457
[ PSA ]:
56.79000
[ LogP ]:
1.32
[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C
[ Index of Refraction ]:
1.521
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- RQ3500000
- CHEMICAL NAME :
- 2-Oxazolidinone, 5-((o-methoxyphenoxy)methyl)-
- CAS REGISTRY NUMBER :
- 70-07-5
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C11-H13-N-O4
- MOLECULAR WEIGHT :
- 223.25
- WISWESSER LINE NOTATION :
- T5MVOTJ D1OR BO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3820 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - ptosis Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 6,642,1964
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 134,198,1961
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5. Volume(issue)/page/year: 11,212,1970
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- RAMAAB Revista de la Asociacion Medica Argentina. (Buenos Aires, Argentina) V.1-89, 1915-76. Discontinued. Volume(issue)/page/year: 74,82,1960 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 30330 mg/kg/30D-C
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in ovarian weight
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,220,1962
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 18 gm/kg/30D-I
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Liver - other changes Blood - normocytic anemia
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,220,1962
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 87 gm/kg/26W-I
- TOXIC EFFECTS :
- Behavioral - ataxia Blood - normocytic anemia
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,220,1962
Safety Information
[ HS Code ]:
2934999090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2934999090
[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%