mephenoxalone

Modify Date: 2026-07-03 11:20:31

mephenoxalone structure	Common Name	mephenoxalone
	CAS Number	70-07-5	Molecular Weight	223.23
	Density	1.2±0.1 g/cm3	Boiling Point	440.0±18.0 °C at 760 mmHg
	Molecular Formula	C₁₁H₁₃NO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	219.9±21.2 °C

Use of mephenoxalone

Mephenoxalone inhibits neuron transmission and can relax skeletal muscles by inhibiting the reflex arc[1].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	5-((2-Methoxyphenoxy)methyl)oxazolidin-2-one
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Mephenoxalone inhibits neuron transmission and can relax skeletal muscles by inhibiting the reflex arc[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. K F BENITZ, et al. Toxicity studies on mephenoxalone in rats and dogs. Toxicol Appl Pharmacol (IF: 4.22; Q2). 1962 Mar;4:220-37.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.2±0.1 g/cm3
Boiling Point	440.0±18.0 °C at 760 mmHg
Molecular Formula	C₁₁H₁₃NO₄
Molecular Weight	223.23
Flash Point	219.9±21.2 °C
Exact Mass	223.084457
PSA	56.79000
LogP	1.32
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.521
InChIKey	ZMNSRFNUONFLSP-UHFFFAOYSA-N
SMILES	COc1ccccc1OCC1CNC(=O)O1

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RQ3500000

CHEMICAL NAME :: 2-Oxazolidinone, 5-((o-methoxyphenoxy)methyl)-

CAS REGISTRY NUMBER :: 70-07-5

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C11-H13-N-O4

MOLECULAR WEIGHT :: 223.25

WISWESSER LINE NOTATION :: T5MVOTJ D1OR BO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3820 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 6,642,1964

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 134,198,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5. Volume(issue)/page/year: 11,212,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RAMAAB Revista de la Asociacion Medica Argentina. (Buenos Aires, Argentina) V.1-89, 1915-76. Discontinued. Volume(issue)/page/year: 74,82,1960 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 30330 mg/kg/30D-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in ovarian weight

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,220,1962

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 18 gm/kg/30D-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Liver - other changes Blood - normocytic anemia

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,220,1962

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 87 gm/kg/26W-I

TOXIC EFFECTS :: Behavioral - ataxia Blood - normocytic anemia

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,220,1962

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

HS Code	2934999090

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

3-propionyl-2-o...

CAS#:60420-27-1

3,3-Dimethylall...

CAS#:870-63-3

~10%

mephenoxalone

CAS#:70-07-5

Learn More

Literature: Smith III, Amos B.; Hirschmann, Ralph F.; Nittoli, Thomas; Sprengeler, Paul Patent: US2002/123635 A1, 2002 ;

Carbon dioxide

CAS#:124-38-9

N/A

CAS#:943962-56-9

~90%

mephenoxalone

CAS#:70-07-5

Learn More

Literature: Madhusudhan; Reddy, M. Srinivasa; Reddy, Y. Narayana; Vijayalakshmi; Suribabu; Balraju Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2010 , vol. 49, # 7 p. 978 - 984

Potassium cyanate

CAS#:590-28-3

1-chloro-3-(2-m...

CAS#:25772-81-0

~66%

mephenoxalone

CAS#:70-07-5

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Literature: Chinnam Naidu; Ravi Babu; Gangaiah; Mukkanti; Madhusudhan Tetrahedron Letters, 2010 , vol. 51, # 8 p. 1226 - 1229

Guaifenesin

CAS#:93-14-1

Urea

CAS#:57-13-6

mephenoxalone

CAS#:70-07-5

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Literature: Lunsford,C.D. et al. Journal of the American Chemical Society, 1960 , vol. 82, p. 1166 - 1171

4-acetamidophen...

CAS#:153756-96-8

4-Acetamidophenol

CAS#:103-90-2

mephenoxalone

CAS#:70-07-5

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Literature: Vigroux, Alain; Bergon, Michel; Zedde, Chantal Journal of Medicinal Chemistry, 1995 , vol. 38, # 20 p. 3983 - 3994

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 7
CAS#:60420-27-1 3-propionyl-2-o... CAS#:870-63-3 3,3-Dimethylall... CAS#:124-38-9 Carbon dioxide CAS#:590-28-3 Potassium cyanate
CAS#:93-14-1 Guaifenesin CAS#:57-13-6 Urea CAS#:153756-96-8 4-acetamidophen...
DownStream 3
CAS#:366789-02-8 Rivaroxaban CAS#:77943-39-6 (4R,5S)-4-Methy... CAS#:104-21-2 Anisyl acetate

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482

Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ...
Source: 824
Target: N/A
External Id: P53MS837

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS898

Name: Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approve...
Source: NCGC
Target: N/A
External Id: OBG420

Total 246, Current Page 1 of 25

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Control-OM

5-[(2-Methoxyphenoxy)methyl]-1,3-oxazolidin-2-one

Mefenoxalona

Mefenoxalone

EINECS 200-723-3

mephenoxalone

5-({[2-(methyloxy)phenyl]oxy}methyl)-1,3-oxazolidin-2-one

Moderamin

Methoxydone

5-[(2-Methoxyphenoxy)methyl]-2-oxazolidinone

Methoxydon

Dorsiflex

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the SMILES notation of 5-((2-Methoxyphenoxy)methyl)oxazolidin-2-one?

A: SMILES notation of 5-((2-Methoxyphenoxy)methyl)oxazolidin-2-one is COc1ccccc1OCC1CNC(=O)O1.

Q: What is the CAS number of 5-((2-Methoxyphenoxy)methyl)oxazolidin-2-one?

A: CAS number of 5-((2-Methoxyphenoxy)methyl)oxazolidin-2-one is 70-07-5.

Q: What is the boiling point of 5-((2-Methoxyphenoxy)methyl)oxazolidin-2-one?

A: Boiling point of 5-((2-Methoxyphenoxy)methyl)oxazolidin-2-one is 440.0±18.0 °C at 760 mmHg.

Q: What are the uses of 5-((2-Methoxyphenoxy)methyl)oxazolidin-2-one?

A: Main uses of 5-((2-Methoxyphenoxy)methyl)oxazolidin-2-one: Mephenoxalone inhibits neuron transmission and can relax skeletal muscles by inhibiting the reflex arc[1].

Q: What is the InChIKey of 5-((2-Methoxyphenoxy)methyl)oxazolidin-2-one?

A: InChIKey of 5-((2-Methoxyphenoxy)methyl)oxazolidin-2-one is ZMNSRFNUONFLSP-UHFFFAOYSA-N.

Q: What is the molecular formula of 5-((2-Methoxyphenoxy)methyl)oxazolidin-2-one?

A: Molecular formula of 5-((2-Methoxyphenoxy)methyl)oxazolidin-2-one is C11H13NO4.

Q: What is the LogP of 5-((2-Methoxyphenoxy)methyl)oxazolidin-2-one?

A: LogP of 5-((2-Methoxyphenoxy)methyl)oxazolidin-2-one is 1.32.

Q: What is the English name of 5-((2-Methoxyphenoxy)methyl)oxazolidin-2-one?

A: The English name of 5-((2-Methoxyphenoxy)methyl)oxazolidin-2-one is 5-((2-Methoxyphenoxy)methyl)oxazolidin-2-one.

Q: What is the polar surface area (PSA) of 5-((2-Methoxyphenoxy)methyl)oxazolidin-2-one?

A: Polar surface area (PSA) of 5-((2-Methoxyphenoxy)methyl)oxazolidin-2-one is 56.79000.

Q: What are the upstream materials of 5-((2-Methoxyphenoxy)methyl)oxazolidin-2-one?

A: Related upstream materials(CAS) of 5-((2-Methoxyphenoxy)methyl)oxazolidin-2-one: 60420-27-1;870-63-3;124-38-9;590-28-3;93-14-1;57-13-6;153756-96-8.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Dayang Chem (Hangzhou) Co., Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: mephenoxalone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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