TCMDC-124283

Suppliers

Names

[ CAS No. ]:
700-49-2

[ Name ]:
TCMDC-124283

[Synonym ]:
2-fluoro-adenin
2-FLUORO-6-AMINOPURINE
7H-Purin-6-amine, 2-fluoro-
2-fluoro-9H-purin-6-amine
2-Fluoroadenine
6-AMINO-2-FLUOROPURINE
TCMDC-124283
MFCD01632749
2-fluoropurine
2-fluoroadenibe
2-Fluoro-1H-purin-6-amine
2-fad
6-amino-2-fluoro-purin
BUTTPARK 25 1-01
2-fluoradenine
2-fluoro-1h-purin-6-amin

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
676.9±58.0 °C at 760 mmHg

[ Melting Point ]:
>350 °C(lit.)

[ Molecular Formula ]:
C₅H₄FN₅

[ Molecular Weight ]:
153.12

[ Flash Point ]:
363.2±32.3 °C

[ Exact Mass ]:
153.045074

[ PSA ]:
80.48000

[ LogP ]:
-0.01

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.783

[ Storage condition ]:
Refrigerator

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU6264700

CHEMICAL NAME :: Adenine, 2-fluoro-

CAS REGISTRY NUMBER :: 700-49-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C5-H4-F-N5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 11340 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
AU6264700

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Adenosine,5'-deoxy-2-fluoro-
6-azido-2-fluoro-7H-purine
1,3-Propanedithiol
2,6-Diaminopurine
2-Fluoroadenosine
Adenosine,2'-deoxy-2-fluoro-
9H-Purin-6-amine, 9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-2-fluoro-

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Reduced drug incorporation into DNA and antiapoptosis as the crucial mechanisms of resistance in a novel nelarabine-resistant cell line.

BMC Cancer 14 , 547, (2014)

Nine-beta-D-arabinofuranosylguanine (ara-G), an active metabolite of nelarabine, enters leukemic cells through human Equilibrative Nucleoside Transporter 1, and is then phosphorylated to an intracellu...

Endothelin-1 promotes survival and chemoresistance in chronic lymphocytic leukemia B cells through ETA receptor.

PLoS ONE 9(6) , e98818, (2014)

The endothelin axis, comprising endothelins (ET-1, ET-2 and ET-3) and their receptors (ET(A)R and ETBR), has emerged as relevant player in tumor growth and metastasis. Here, we investigated the involv...

Preparation of a fludarabine intermediate via selective alkylation of 2-fluoroadenine.

Nucleosides Nucleotides Nucleic Acids 25(7) , 735-45, (2006)

The reaction between 2-fluoroadenine (3) and 1,3,5-tri-O-benzyl-1-alpha-D-chloroarabinofuranose (4) with potassium t-amylate was evaluated in various solvents to afford 9-beta-D-(2,3,5-tri-O-benzyl-ar...