TCMDC-124283

Modify Date: 2025-08-25 13:39:34

TCMDC-124283 structure	Common Name	TCMDC-124283
	CAS Number	700-49-2	Molecular Weight	153.12
	Density	1.7±0.1 g/cm3	Boiling Point	676.9±58.0 °C at 760 mmHg
	Molecular Formula	C₅H₄FN₅	Melting Point	>350 °C(lit.)
	MSDS	Chinese USA	Flash Point	363.2±32.3 °C
	Symbol	GHS07	Signal Word	Warning

Use of TCMDC-124283

2-Fluoroadenine is a toxic purine bases. 2-Fluoroadenine has toxicity in nonproliferating and proliferating tumor cells. 2-Fluoroadenine can be used for researching anticancer[1].

Name	2-fluoroadenine
Synonym	More Synonyms

Description	2-Fluoroadenine is a toxic purine bases. 2-Fluoroadenine has toxicity in nonproliferating and proliferating tumor cells. 2-Fluoroadenine can be used for researching anticancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
Target	DNA/RNA synthesis[1]
In Vitro	2-Fluoroadenine (2 μM; 4 hours) inhibits CEM cell growth by targeting one or more enzymes involved in either RNA or protein synthesis[1]. 2-Fluoroadenine (0-1000 μM; 96 hours) exhibits cytotoxicity in nonproliferating MRC-5 cells[1]. 2-Fluoroadenine (0.22, 2.2 and 22 μM; 30 hours) inhibits protein, RNA, and DNA syntheses in Balb-3T3 cells incubated in serum-free medium[1]. Cell Proliferation Assay Cell Line: CEM cells[1] Concentration: 2 μM Incubation Time: 4 hours Result: Inhibited CEM cell growth by targeting one or more enzymes involved in either RNA or protein synthesis. Cell Cytotoxicity Assay Cell Line: MRC-5 cells[1] Concentration: 0-1000 μM Incubation Time: 4 hours Result: Exhibited cytotoxicity in nonproliferating MRC-5 cells.
References	[1]. Parker WB, et al. Metabolism and metabolic actions of 6-methylpurine and 2-fluoroadenine in human cells. Biochem Pharmacol. 1998;55(10):1673-1681.

Density	1.7±0.1 g/cm3
Boiling Point	676.9±58.0 °C at 760 mmHg
Melting Point	>350 °C(lit.)
Molecular Formula	C₅H₄FN₅
Molecular Weight	153.12
Flash Point	363.2±32.3 °C
Exact Mass	153.045074
PSA	80.48000
LogP	-0.01
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.783
InChIKey	WKMPTBDYDNUJLF-UHFFFAOYSA-N
SMILES	Nc1nc(F)nc2nc[nH]c12
Storage condition	Refrigerator

TCMDC-124283 MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU6264700

CHEMICAL NAME :: Adenine, 2-fluoro-

CAS REGISTRY NUMBER :: 700-49-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C5-H4-F-N5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 11340 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	AU6264700
HS Code	2933990090

Adenosine,5'-de...

CAS#:37076-78-1

TCMDC-124283

CAS#:700-49-2

Literature: WO2006/81665 A1, ; Page/Page column 26-27 ;

6-azido-2-fluor...

CAS#:143482-58-0

TCMDC-124283

CAS#:700-49-2

Literature: US5180824 A1, ;

1,3-Propanedithiol

CAS#:109-80-8

6-azido-2-fluor...

CAS#:143482-58-0

TCMDC-124283

CAS#:700-49-2

Literature: US5180824 A1, ;

2,6-Diaminopurine

CAS#:1904-98-9

~60%

TCMDC-124283

CAS#:700-49-2

Literature: SAISCHEK, Gerald Patent: US2009/163713 A1, 2009 ; Location in patent: Page/Page column 2 ;

2-Fluoroadenosine

CAS#:146-78-1

TCMDC-124283

CAS#:700-49-2

ribofuranose-1-...

CAS#:72075-46-8

Literature: Nucleosides and Nucleotides, , vol. 18, # 4-5 p. 745 - 757

Adenosine,2'-de...

CAS#:21679-12-9

2-deoxy-α-D-rib...

CAS#:17039-17-7

TCMDC-124283

CAS#:700-49-2

Literature: Nucleosides and Nucleotides, , vol. 18, # 4-5 p. 745 - 757

2-Fluoroadenosine

CAS#:146-78-1

TCMDC-124283

CAS#:700-49-2

α-D-ribofuranos...

CAS#:18646-11-2

Literature: Nucleosides and Nucleotides, , vol. 18, # 4-5 p. 745 - 757

9H-Purin-6-amin...

CAS#:134217-15-5

TCMDC-124283

CAS#:700-49-2

α-2d2F-Ara-1-P

CAS#:850883-62-4

Literature: Nucleosides and Nucleotides, , vol. 18, # 4-5 p. 745 - 757

Precursor 7
CAS#:37076-78-1 Adenosine,5'-de... CAS#:143482-58-0 6-azido-2-fluor... CAS#:109-80-8 1,3-Propanedithiol CAS#:1904-98-9 2,6-Diaminopurine
CAS#:146-78-1 2-Fluoroadenosine CAS#:21679-12-9 Adenosine,2'-de... CAS#:134217-15-5 9H-Purin-6-amin...
DownStream 3
CAS#:146-78-1 2-Fluoroadenosine CAS#:21679-12-9 Adenosine,2'-de... CAS#:86626-06-4 3-(6-amino-2-fl...

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Reduced drug incorporation into DNA and antiapoptosis as the crucial mechanisms of resistance in a novel nelarabine-resistant cell line.

BMC Cancer 14 , 547, (2014)

Nine-beta-D-arabinofuranosylguanine (ara-G), an active metabolite of nelarabine, enters leukemic cells through human Equilibrative Nucleoside Transporter 1, and is then phosphorylated to an intracellu...

Endothelin-1 promotes survival and chemoresistance in chronic lymphocytic leukemia B cells through ETA receptor.

PLoS ONE 9(6) , e98818, (2014)

The endothelin axis, comprising endothelins (ET-1, ET-2 and ET-3) and their receptors (ET(A)R and ETBR), has emerged as relevant player in tumor growth and metastasis. Here, we investigated the involv...

Preparation of a fludarabine intermediate via selective alkylation of 2-fluoroadenine.

Nucleosides Nucleotides Nucleic Acids 25(7) , 735-45, (2006)

The reaction between 2-fluoroadenine (3) and 1,3,5-tri-O-benzyl-1-alpha-D-chloroarabinofuranose (4) with potassium t-amylate was evaluated in various solvents to afford 9-beta-D-(2,3,5-tri-O-benzyl-ar...

Name: ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania ...
Source: ChEMBL
Target: Glucose transporter
External Id: CHEMBL3436044

Name: Biochemical screen of P. falciparum CDPK1
Source: 1187
Target: Calcium-Dependent Protein Kinase 1 (CDPK1)
External Id: PfalCDPK1

Name: Trypanocidal activity against bloodstream stage of Trypanosoma brucei brucei AnTat1.1...
Source: ChEMBL
Target: Trypanosoma brucei brucei
External Id: CHEMBL3110905

Name: ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania ...
Source: ChEMBL
Target: Solute carrier family 2, facilitated glucose transporter member 1
External Id: CHEMBL3436042

Name: Biochemical screen of P. falciparum PK7
Source: 1187
Target: Protein Kinase 7 (PK7)
External Id: PfalPK7

Name: ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania ...
Source: ChEMBL
Target: Hexose transporter 1
External Id: CHEMBL3436043

Name: Biochemical screen of P. falciparum PK6
Source: 1187
Target: Protein Kinase 6 (PK6)
External Id: PfalPK6

Name: Biochemical screen of P. falciparum MAPK2
Source: 1187
Target: mitogen-activated protein kinase 2 (MAP2 or MAPK2)
External Id: PfalMAPK2

Name: Biochemical screen of P. falciparum CDPK4
Source: 1187
Target: Calcium-Dependent Protein Kinase 4 (CDPK4)
External Id: PfalCDPK4

Name: Inhibition of ATPgammaS-BODIPY binding to Thermotoga maritima His-tagged HK853 expres...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4020051

Total 10, Current Page 1 of 1

2-fluoro-adenin

2-FLUORO-6-AMINOPURINE

2-fluoro-9H-purin-6-amine

2-Fluoroadenine

6-AMINO-2-FLUOROPURINE

TCMDC-124283

MFCD01632749

2-fluoropurine

2-fluoroadenibe

2-Fluoro-1H-purin-6-amine

2-fad

6-amino-2-fluoro-purin

BUTTPARK 25 1-01

2-fluoradenine

2-fluoro-1h-purin-6-amin

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: TCMDC-124283
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-Fluoroadenine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: TCMDC-124283
Price: ￥968.0/1g
Purity: 95.0%
Delivery: 2 Day
Contact: Liu jia
Email: 2130147988@qq.com

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TCMDC-124283

Use of TCMDC-124283

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TCMDC-124283 Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Synthetic Route

Precursor & DownStream

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Articles17

TCMDC-124283Bioassay

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.