(S)-(+)-4-Amino-3-hydroxybutyric acid

Suppliers

Names

[ Name ]:
(S)-(+)-4-Amino-3-hydroxybutyric acid

[Synonym ]:
3-Hydroxy-4-aminobutyric acid
γ-amino-β-hydroxybutyric acid
(S)-4-AMINO-3-HYDROXYBUTANOIC ACID
3-hydroxy-4-amino-butyric acid (GABOB)
3-hydroxy-GABA
β-Hydroxy-GABA
3-hydroxy-4-amino-butyric acid
Butanoic acid, 4-amino-3-hydroxy-
(S)-(+)-GABOB
acide (S)-amino-4 hydroxy-3 butanoique
β-Hydroxy-γ-aminobutyric acid
4-Amino-3-hydroxybutanoic acid
(S)-(+)-Amino-3-hydroxybutanoic acid
g-Amino-b-hydroxybutyric Acid
DL-4-Amino-3-hydroxybutanoic acid
DL-4-Amino-3-hydroxybutyric acid
(S)-(+)-4-Amino-3-hydroxybutyric acid
MFCD00672884
(±)-4-Amino-3-hydroxybutyric acid
γ-Amino-β-hydroxy-n-butyric acid
UNII:1ZHM019FLD

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
374.5±32.0 °C at 760 mmHg

[ Melting Point ]:
207-212ºC

[ Molecular Formula ]:
C₄H₉NO₃

[ Molecular Weight ]:
119.119

[ Flash Point ]:
180.3±25.1 °C

[ Exact Mass ]:
119.058243

[ PSA ]:
83.55000

[ LogP ]:
-1.73

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.511

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4-(((benzyloxy)carbonyl)amino)-3-hydroxybutanoic acid
(-)-ethyl 3-cyano-3-hydroxypropionate
(S)-4-chloro-3-hydroxybutanamide
[(5S)-2-oxo-1,3-oxazolidin-5-yl]acetic acid
acide (S)-benzamido-4 hydroxy-3 butanoique
3,4 epoxybutyric acid
(2R)-2-(tert-Butyl)-3-methoxycarbonyl-1,3-oxazolidin-5-ylessigsaeure

DownStream

Articles

Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABA(C) receptors.

Bioorg. Med. Chem. Lett. 18 , 402-4, (2008)

The R- and S-enantiomers of 4-amino-3-hydroxybutanoic acid (GABOB) were full agonists at human recombinant rho1 GABA(C) receptors. Their enantioselectivity (R>S) matched that reported for their agonis...

GABA agonists. Resolution, absolute stereochemistry, and enantioselectivity of (S)-(+)- and (R)-(-)-dihydromuscimol.

J. Med. Chem. 28(11) , 1612-7, (1985)

(RS)-5-(Aminomethyl)-2-isoxazolin-3-ol (dihydromuscimol, DHM) is a potent 4-aminobutyric acid (GABA) agonist, the inhibitory effects of which on neurons are sensitive to the antagonist bicuculline met...

Formation of gamma-amino-beta-hydroxybutyric acid from 2-hydroxyputrescine in rat brain.

J. Neurochem. 51(2) , 548-51, (1988)

gamma-Amino-beta-[3H]hydroxybutyric acid ([3H]-GABOB) was formed in rat brain from 2-[3H]-hydroxyputrescine that had been chemically synthesized from 2-oxoputrescine and [3H]sodium borohydride. After ...

(S)-(+)-4-Amino-3-hydroxybutyric acid
z-4-amino-3-hydroxybutyric acid
DL-γ-Amino-β-hydroxybutyric acid
Methyl (3S)-3-hydroxybutanoate
(S)-(+)-4-(2-amino-3-chloropropyl)-imidazole dihydrochloride
(s)-4-amino-3-p-tolylbutanoic acid