Veratridine

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Names

[ CAS No. ]:
71-62-5

[ Name ]:
Veratridine

[Synonym ]:
Metergoline
,4alpha,16beta)
EINECS 200-758-4
Veracevine,veratrate
ybenzoate)
VERATRIDINE
3-VERATROYLVERACEVINE
MFCD00082515

Chemical & Physical Properties

[ Density]:
1.45 g/cm3

[ Boiling Point ]:
814.5ºC at 760 mmHg

[ Melting Point ]:
180ºC

[ Molecular Formula ]:
C36H51NO11

[ Molecular Weight ]:
673.79000

[ Flash Point ]:
446.4ºC

[ Exact Mass ]:
673.34600

[ PSA ]:
178.61000

[ LogP ]:
1.29390

[ Index of Refraction ]:
1.663

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YX5600000
CHEMICAL NAME :
Veratridine
CAS REGISTRY NUMBER :
71-62-5
BEILSTEIN REFERENCE NO. :
0078875
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C36-H51-N-O11
MOLECULAR WEIGHT :
673.88
WISWESSER LINE NOTATION :
T J6 H6 E6 D5665/TC& 3ATU C& ON TX C&OTJ EQ GQ HQ IQ I1 M1 RQ U1 A&OVR CO1 DO1& B&Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3500 ug/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 78,238,1943
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1350 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 76,847,1951
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6300 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 113,89,1955
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
19 mg/kg
TOXIC EFFECTS :
Cardiac - arrhythmias (including changes in conduction)
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 120,412,1957

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300 + H310 + H330-H315-H319-H335-H361-H373-H412

[ Precautionary Statements ]:
P260-P262-P280-P301 + P310 + P330-P302 + P352 + P310-P304 + P340 + P310-P403 + P233

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T+: Very toxic;

[ Risk Phrases ]:
R26/27/28

[ Safety Phrases ]:
S26;S36/S37/S39;S45

[ RIDADR ]:
UN 1544 6

[ WGK Germany ]:
2

[ RTECS ]:
YX5600000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

[ HS Code ]:
2929101000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • veratroyl chloride

DownStream

  • Veratric acid
  • Cevane-3,4,12,14,16,17,20-heptol,4,9-epoxy-, (3a,4a,16b)-

Customs

[ HS Code ]: 2929101000

[ Summary ]:
2929101000. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

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Ikarisoside A is a natural flavonol glycoside derived from plants of the genus Epimedium, which have been used in Traditional Chinese Medicine as tonics, antirheumatics, and aphrodisiacs. Here, we rep...

Contribution to the risk characterization of ciguatoxins: LOAEL estimated from eight ciguatera fish poisoning events in Guadeloupe (French West Indies).

Environ. Res. 143 , 100-8, (2015)

From 2010 to 2012, 35 ciguatera fish poisoning (CFP) events involving 87 individuals who consumed locally-caught fish were reported in Guadeloupe (French West Indies). For 12 of these events, the pres...

Voltage-activated calcium channels involved in veratridine-evoked [3H]dopamine release in rat striatal slices.

Neuropharmacology 37 , 973-982, (1998)

The present study explored the role of different sub-types of voltage-activated Ca2+ channels (VACCs) in mediating veratridine-evoked [3H]dopamine (DA) release from rat striatal slices. The release of...


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