Veratridine
Modify Date: 2025-08-20 13:05:36
Veratridine structure
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Common Name | Veratridine | ||
|---|---|---|---|---|
| CAS Number | 71-62-5 | Molecular Weight | 673.79000 | |
| Density | 1.45 g/cm3 | Boiling Point | 814.5ºC at 760 mmHg | |
| Molecular Formula | C36H51NO11 | Melting Point | 180ºC | |
| MSDS | Chinese USA | Flash Point | 446.4ºC | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
Use of VeratridineVeratridine (3-Veratroylveracevine), a alkaloid derived from plants in the family Liliaceae, is a sodium channel agonist. Veratridine inhibits the peak current of Nav1.7, with an IC50 of 18.39 µM. |
| Name | veratridine |
|---|---|
| Synonym | More Synonyms |
| Description | Veratridine (3-Veratroylveracevine), a alkaloid derived from plants in the family Liliaceae, is a sodium channel agonist. Veratridine inhibits the peak current of Nav1.7, with an IC50 of 18.39 µM. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.45 g/cm3 |
|---|---|
| Boiling Point | 814.5ºC at 760 mmHg |
| Melting Point | 180ºC |
| Molecular Formula | C36H51NO11 |
| Molecular Weight | 673.79000 |
| Flash Point | 446.4ºC |
| Exact Mass | 673.34600 |
| PSA | 178.61000 |
| LogP | 1.29390 |
| Index of Refraction | 1.663 |
| InChIKey | FVECELJHCSPHKY-YFUMOZOISA-N |
| SMILES | COc1ccc(C(=O)OC2CCC3(C)C4CCC5C6(O)CC(O)C7(O)C(CN8CC(C)CCC8C7(C)O)C6(O)CC53OC24O)cc1OC |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Symbol |
GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H300 + H310 + H330-H315-H319-H335-H361-H373-H412 |
| Precautionary Statements | P260-P262-P280-P301 + P310 + P330-P302 + P352 + P310-P304 + P340 + P310-P403 + P233 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T+: Very toxic; |
| Risk Phrases | R26/27/28 |
| Safety Phrases | S26;S36/S37/S39;S45 |
| RIDADR | UN 1544 6 |
| WGK Germany | 2 |
| RTECS | YX5600000 |
| Packaging Group | II |
| Hazard Class | 6.1(a) |
| HS Code | 2929101000 |
|
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Veratridine CAS#:71-62-5 |
| Literature: Collection of Czechoslovak Chemical Communications, , vol. 22, p. 98,102 |
| Precursor 1 | |
|---|---|
| DownStream 2 | |
CAS#:93-07-2
CAS#:124-98-1| HS Code | 2929101000 |
|---|---|
| Summary | 2929101000. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Ikarisoside A inhibits acetylcholine-induced catecholamine secretion and synthesis by suppressing nicotinic acetylcholine receptor-ion channels in cultured bovine adrenal medullary cells.
Naunyn Schmiedebergs Arch. Pharmacol. 388 , 1259-69, (2015) Ikarisoside A is a natural flavonol glycoside derived from plants of the genus Epimedium, which have been used in Traditional Chinese Medicine as tonics, antirheumatics, and aphrodisiacs. Here, we rep... |
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Contribution to the risk characterization of ciguatoxins: LOAEL estimated from eight ciguatera fish poisoning events in Guadeloupe (French West Indies).
Environ. Res. 143 , 100-8, (2015) From 2010 to 2012, 35 ciguatera fish poisoning (CFP) events involving 87 individuals who consumed locally-caught fish were reported in Guadeloupe (French West Indies). For 12 of these events, the pres... |
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Voltage-activated calcium channels involved in veratridine-evoked [3H]dopamine release in rat striatal slices.
Neuropharmacology 37 , 973-982, (1998) The present study explored the role of different sub-types of voltage-activated Ca2+ channels (VACCs) in mediating veratridine-evoked [3H]dopamine (DA) release from rat striatal slices. The release of... |
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Name: Rat Nav1.5 (Voltage-gated sodium channels)
Source: IUPHAR-DB
Target: Nav1.5 (Voltage-gated sodium channels) [Rattus norvegicus]
External Id: 582_Rat
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Name: Displacement of [3H]batrachotoxinin from sodium channel site 2 at 10 uM relative to v...
Source: ChEMBL
Target: N/A
External Id: CHEMBL922356
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|
Name: Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: HCMV UL50
External Id: HMS1262
|
|
Name: Chemical Probes of Kaposi's Sarcoma Herpes Virus Latent Infection
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: ORF 73 [Human herpesvirus 8 type M]
External Id: HMS791
|
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Name: Human Nav1.7 (Voltage-gated sodium channels)
Source: IUPHAR-DB
Target: Nav1.7 (Voltage-gated sodium channels) [Homo sapiens]
External Id: 584_Human
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Name: Rat Nav1.4 (Voltage-gated sodium channels)
Source: IUPHAR-DB
Target: Nav1.4 (Voltage-gated sodium channels) [Rattus norvegicus]
External Id: 581_Rat
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Name: Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimo...
Source: ChEMBL
Target: Solute carrier organic anion transporter family member 1B3
External Id: CHEMBL3039491
|
|
Name: A screen for compounds that inhibit viral RNA polymerase binding and polymerization a...
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: Chain A, Poliovirus Polymerase With Gtp
External Id: HMS750
|
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| Metergoline |
| ,4alpha,16beta) |
| EINECS 200-758-4 |
| Veracevine,veratrate |
| ybenzoate) |
| VERATRIDINE |
| 3-VERATROYLVERACEVINE |
| MFCD00082515 |