2-(Difluoromethoxy)benzaldehyde

Names

[ Name ]:
2-(Difluoromethoxy)benzaldehyde

[Synonym ]:
Benzaldehyde, 2-(difluoromethoxy)-
MFCD00042251
2-(Difluoromethoxy)benzaldehyde
α,α-Difluoro-o-anisaldehyde
VHR BOYFF

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
226.6±30.0 °C at 760 mmHg

[ Molecular Formula ]:
C₈H₆F₂O₂

[ Molecular Weight ]:
172.129

[ Flash Point ]:
88.4±19.4 °C

[ Exact Mass ]:
172.033585

[ PSA ]:
26.30000

[ LogP ]:
1.89

[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.498

MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2913000090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Salicylaldehyde
Difluorochloromethane
(Bromodifluoromethyl)trimethylsilane

DownStream

5-acetyl-4-[2-(difluoromethoxy)phenyl]-6-methyl-3,4-dihydro-1H-pyrimidin-2-one
methyl 6-[2-(difluoromethoxy)phenyl]-3,4-dimethyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate
bis(2-methylpropyl) 4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
3-[2-(DIFLUOROMETHOXY)PHENYL]ACRYLIC ACID
3-AMINO-3-(2-DIFLUOROMETHOXYPHENYL)-PROPIONIC ACID
ethyl 5-cyano-4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate
4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-3-N,5-N-diphenyl-1,4-dihydropyridine-3,5-dicarboxamide
methyl 5-cyano-4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate
ethyl 4-[2-(difluoromethoxy)phenyl]-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate
ditetradecyl 4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Customs

[ HS Code ]: 2913000090

[ Summary ]:
HS: 2913000090 halogenated, sulphonated, nitrated or nitrosated derivatives of products of heading 2912 Educational tariff:17.0% Tax rebate rate:9.0% Regulatory conditions:none Most favored nation tariff:5.5% General tariff:30.0%

Articles

Effect of acyl chain length and branching on the enantioselectivity of Candida rugosa lipase in the kinetic resolution of 4-(2-difluoromethoxyphenyl)-substituted 1,4-dihydropyridine 3,5-diesters.

J. Org. Chem. 67(2) , 401-10, (2002)

Since 2,6-dimethyl-4-aryl-1,4-dihydropyridine 3,5-diesters themselves are not hydrolyzed by commercially available hydrolases, derivatives with spacers containing a hydrolyzable group were prepared. S...

Synthesis of 3-alkoxycarbonyl-6-alkylsulfanyl-4-[2-(difluoromethoxy) phenyl]-1, 4-dihydropyridines and related derivatives as analogs of cognition enhancer cerebrocrast. Krauze A, et al.

Chem. Heterocycl. Comp. 49(4) , 566-73, (2013)

Synthesis and enantioselective lipase-catalyzed kinetic resolution of methyl 6-(methoxycarbonyl-methyl) sulfanyl-1, 4-dihydropyridine-3-carboxylates. Andzans Z, et al.

Chem. Heterocycl. Comp. 49(13) , 421-27, (2013)

5-Bromo-2-(difluoromethoxy)benzaldehyde
4-Bromo-2-(difluoromethoxy)benzaldehyde
4-Chloro-2-(difluoromethoxy)benzaldehyde
5-chloro-2-(difluoromethoxy)benzaldehyde
2-(Difluoromethoxy)-6-fluorobenzaldehyde
2-Difluoromethoxy-3-methoxy-benzaldehyde
rac-[(2R,5S)-5-[(4-methylpiperidin-1-yl)methyl]oxolan-2-yl]methanol
1-(7-Bromo-2,3-dihydro-1-benzofuran-2-yl)-2-cyclopropylethan-1-one
2,6-Difluoro-4-hydroxybenzene-1-sulfonyl fluoride
tert-butyl N-[4-(1-methylcyclobutyl)-3-oxobutan-2-yl]carbamate
2-{1-[(Tert-butoxy)carbonyl]pyrrolidin-2-yl}-5-methyl-1,3-thiazole-4-carboxylic acid
tert-butyl N-[3-oxo-4-(1,3-thiazol-2-yl)butan-2-yl]carbamate
1-Benzyl-3-(2,2-dimethylpropyl)piperazine-2,5-dione
tert-butyl N-(3-cyanocinnolin-4-yl)carbamate
2-(4-Fluoro-2-methyl-5-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
tert-butyl N-[1-(2-methyl-2H-1,2,3,4-tetrazol-5-yl)-1-oxopropan-2-yl]carbamate

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