Vasicine hydrochloride

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Names

[ CAS No. ]:
7174-27-8

[ Name ]:
Vasicine hydrochloride

[Synonym ]:
Peganine monohydrochloride
linarinehydrochloride
Vasicine Hcl

Chemical & Physical Properties

[ Boiling Point ]:
373.8ºC at 760 mmHg

[ Melting Point ]:
206-208ºC

[ Molecular Formula ]:
C₁₁H₁₃ClN₂O

[ Molecular Weight ]:
224.68700

[ Flash Point ]:
179.9ºC

[ Exact Mass ]:
224.07200

[ PSA ]:
35.83000

[ LogP ]:
1.47230

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY9454100

CHEMICAL NAME :: Pyrrolo(2,1-b)quinazolin-3-ol, 1,2,3,9-tetrahydro-, monohydrochloride, (R)-

CAS REGISTRY NUMBER :: 7174-27-8

LAST UPDATED :: 199510

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C11-H12-N2-O.Cl-H

MOLECULAR WEIGHT :: 224.71

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 640 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,474,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 115 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,474,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 335 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,474,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 290 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,474,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,474,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 78200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 49(3),37,1986

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

Deoxyvasicine hydrochloride
Losoxantrone hydrochloride [USAN]
Triprolidine hydrochloride
Elacridar hydrochloride
Tyrocidine, hydrochloride
dodecylamine hydrochloride
2,2-Difluoro-3-(1,2,3,6-tetrahydropyridin-1-yl)propanoic acid
2-(1-{[(Tert-butoxy)carbonyl]amino}cyclohexyl)-2-oxoacetic acid
1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 2-(dimethyl-1,2-oxazol-4-yl)-4-methyl-1,3-thiazole-5-carboxylate
3-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2,2-difluoropropanamido]oxolane-2-carboxylic acid
3-Chlorooxane-3-carbonyl chloride
rac-(2R,3S)-3-{2-ethyl-2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]butanamido}oxolane-2-carboxylic acid
1-[5-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylpentanoyl]azepane-2-carboxylic acid
1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 2-(2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetate
7-(Iodomethyl)-8-oxadispiro[2.2.4^{6}.2^{3}]dodecan-9-one
(1S,5R)-2'-(iodomethyl)spiro[bicyclo[3.2.1]octane-3,3'-oxolane]-5'-one

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