Vasicine hydrochloride

Modify Date: 2024-01-13 16:57:55

Vasicine hydrochloride structure	Common Name	Vasicine hydrochloride
	CAS Number	7174-27-8	Molecular Weight	224.68700
	Density	N/A	Boiling Point	373.8ºC at 760 mmHg
	Molecular Formula	C₁₁H₁₃ClN₂O	Melting Point	206-208ºC
	MSDS	N/A	Flash Point	179.9ºC

Use of Vasicine hydrochloride

Vasicine hydrochloride (peganine hydrochloride) is a quinazoline alkaloid isolated from Justicia adhatoda. Vasicine (peganine) possesses anti- tuberculosis activity[1].

Name	(3S)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-3-ol,hydrochloride
Synonym	More Synonyms

Description	Vasicine hydrochloride (peganine hydrochloride) is a quinazoline alkaloid isolated from Justicia adhatoda. Vasicine (peganine) possesses anti- tuberculosis activity[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. Grange JM, et al. Activity of bromhexine and ambroxol, semi-synthetic derivatives of vasicine from the Indian shrub Adhatoda vasica, against Mycobacterium tuberculosis in vitro. J Ethnopharmacol. 1996 Jan;50(1):49-53.

Boiling Point	373.8ºC at 760 mmHg
Melting Point	206-208ºC
Molecular Formula	C₁₁H₁₃ClN₂O
Molecular Weight	224.68700
Flash Point	179.9ºC
Exact Mass	224.07200
PSA	35.83000
LogP	1.47230

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY9454100

CHEMICAL NAME :: Pyrrolo(2,1-b)quinazolin-3-ol, 1,2,3,9-tetrahydro-, monohydrochloride, (R)-

CAS REGISTRY NUMBER :: 7174-27-8

LAST UPDATED :: 199510

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C11-H12-N2-O.Cl-H

MOLECULAR WEIGHT :: 224.71

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 640 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,474,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 115 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,474,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 335 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,474,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 290 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,474,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,474,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 78200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 49(3),37,1986

vasicol

CAS#:158734-31-7

Vasicine hydroc...

CAS#:7174-27-8

Literature: Dhar, K. L.; Jain, M. P.; Koul, S. K.; Atal, C. K. Phytochemistry (Elsevier), 1981 , vol. 20, p. 319 - 322

(±)-Vasicine

CAS#:6159-56-4

Vasicine hydroc...

CAS#:7174-27-8

Literature: Dhar, K. L.; Jain, M. P.; Koul, S. K.; Atal, C. K. Phytochemistry (Elsevier), 1981 , vol. 20, p. 319 - 322

Precursor 1
CAS#:6159-56-4 (±)-Vasicine
DownStream 1
CAS#:495-59-0 3-deoxyvasicine

Peganine monohydrochloride

linarinehydrochloride

Vasicine Hcl

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (R)-1,2,3,9-TETRAHYDROPYRROLO[2,1-B]QUINAZOLIN-3-OL HYDROCHLORIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Vasicine hydrochloride

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