Metandienone

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Names

[ CAS No. ]:
72-63-9

[ Name ]:
Metandienone

[Synonym ]:
1-Dehydro-17a-methyltestosterone
Androsta-1,4-dien-3-one, 17β-hydroxy-17α-methyl-
Androsta-1,4-dien-3-one, 17β-hydroxy-17-methyl-
1-Dehydro-17α-methyltestosterone
Androsta-1,4-dien-3-one, 17-hydroxy-17-methyl-, (17β)-
EINECS 200-787-2
(17β)-17-Hydroxy-17-methylandrosta-1,4-dien-3-one
17a-Methyl-17b-hydroxyandrosta-1,4-dien-3-one
17-β-hydroxy-17-methyl-androsta-1,4-dien-3-one (9CI)
Metandienone
(17b)-17-Hydroxy-17-methylandrosta-1,4-dien-3-one
Nabolin
17-β-hydroxy-17-methyl-androsta-1,4-dien-3-one
Methandienone
Methandrostenolone
MFCD00003650

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
436.5±45.0 °C at 760 mmHg

[ Melting Point ]:
165-166 °C

[ Molecular Formula ]:
C₂₀H₂₈O₂

[ Molecular Weight ]:
300.435

[ Flash Point ]:
186.2±21.3 °C

[ Exact Mass ]:
300.208923

[ PSA ]:
37.30000

[ LogP ]:
4.04

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.572

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BV8000000

CHEMICAL NAME :: Androsta-1,4-dien-3-one, 17-beta-hydroxy-17-alpha-methyl-

CAS REGISTRY NUMBER :: 72-63-9

LAST UPDATED :: 199504

WISWESSER LINE NOTATION :: L E5 B666 OV AHTTT&J A1 E1 FQ F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 425 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 561 mg/kg/7Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 13 mg/kg

SEX/DURATION :: male 60 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 200 mg/kg

SEX/DURATION :: female 10 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 200 mg/kg

SEX/DURATION :: male 10 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - other effects on male

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 7 mg/kg

SEX/DURATION :: female 14 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Fertility - other measures of fertility

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg/10D (Intermittent)

REFERENCE :: VPITAR Voprosy Pitaniya. Problems of Nutrition. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1932-41; V.11- 1952- Volume(issue)/page/year: 38(4),63,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5642 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 157 (estimated) No. of Female Employees: 72 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H315-H360FD

[ Supplemental HS ]:
May form explosive peroxides.

[ Precautionary Statements ]:
P201-P210-P280-P308 + P313-P370 + P378-P403 + P235

[ Hazard Codes ]:
F,T

[ Risk Phrases ]:
60-61-11-19-38

[ Safety Phrases ]:
53-45

[ RIDADR ]:
3249

[ WGK Germany ]:
3

[ RTECS ]:
BV8000000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2942000000

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