chlorquinaldol
Suppliers
Names
[ CAS No. ]:
72-80-0
[ Name ]:
chlorquinaldol
[Synonym ]:
5,7-Dichloro-2-methyl-8-quinolinol
5,7-Dichloro-8-hydroxyquinaldine
2-methyl-5,7-dichloro-8-hydroxyquinoline
5,7-Dichloro-8-quinaldinol
Clorquinaldol
Chloroquinaldol
EINECS 200-789-3
Gynotherax
5,7-dichloro-2-methylquinolin-8-ol
2-methylchloroxine
5,7-Dichlor-2-methylchinolin-8-ol
Saprosan
Sterosan
5,7-dichloro-2-methyl-8-hydroxy-quinoline
8-Quinolinol, 5,7-dichloro-2-methyl-
chlorquinaldol
Chlorchinaldolum
Chlorquinaldolum
MFCD00023984
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Boiling Point ]:
350.7±37.0 °C at 760 mmHg
[ Melting Point ]:
108-112 °C (dec.)(lit.)
[ Molecular Formula ]:
C10H7Cl2NO
[ Molecular Weight ]:
228.075
[ Flash Point ]:
165.9±26.5 °C
[ Exact Mass ]:
226.990463
[ PSA ]:
33.12000
[ LogP ]:
4.21
[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C
[ Index of Refraction ]:
1.679
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
Insoluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VC5600000
- CHEMICAL NAME :
- 8-Quinolinol, 5,7-dichloro-2-methyl-
- CAS REGISTRY NUMBER :
- 72-80-0
- BEILSTEIN REFERENCE NO. :
- 0156683
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C10-H7-Cl2-N-O
- MOLECULAR WEIGHT :
- 228.08
- WISWESSER LINE NOTATION :
- T66 BNJ C1 GG IG JQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 660 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 2250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 160 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TEST SYSTEM :
- Mold - Aspergillus nidulans
- DOSE/DURATION :
- 1 gm/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 26,159,1974
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302
[ Precautionary Statements ]:
P301 + P312 + P330
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn:Harmful
[ Risk Phrases ]:
R22;R36/37/38
[ Safety Phrases ]:
S26-S36-S36/37/39
[ RIDADR ]:
UN 2811 6.1/PG 3
[ WGK Germany ]:
3
[ RTECS ]:
VC5600000
[ HS Code ]:
2933499090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933499090
[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Acta Pol. Pharm. 70(1) , 51-8, (2013)
The study was aimed at developing a simple HPLC method for the determination of the content of impurities in Gynalgin, a two-component preparation. A satisfactory separation was performed on 250 x 4.6...
Derm. Beruf Umwelt. 36(3) , 86-90, (1988)
Evaluation of our standardized test results from 1972 to 1983 indicated Vioform allergies in 1.2% of all cases and Sterosan allergies in 1.1%. Our results are within the spectrum found in the literatu...
Antimicrob. Agents Chemother. 51 , 1105-6, (2007)
The in vitro activities of cloxyquin (5-chloroquinolin-8-ol) against 9 standard strains and 150 clinical isolates of Mycobacterium tuberculosis were studied. The MICs ranged from 0.062 to 0.25 microg/...