4-Aminophenyl disulfide

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Names

[ CAS No. ]:
722-27-0

[ Name ]:
4-Aminophenyl disulfide

[Synonym ]:
Dithioaniline
4,4'-Diaminodiphenyl disulphide
4-Aminophenyl disulfide
p-p'-Dithiodianiline
4,4'-Dithio-Aniline
4-aminophenyl
{4-[(4-Aminophenyl)dithio]phenyl}amine
4,4'-Disulfanediyldianiline
MFCD00007882
Benzenamine, 4,4'-dithiobis-
EINECS 211-961-2
4,4'-diamino diphenyl disulfide

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
447.0±30.0 °C at 760 mmHg

[ Melting Point ]:
77-78 °C(lit.)

[ Molecular Formula ]:
C12H12N2S2

[ Molecular Weight ]:
248.367

[ Flash Point ]:
224.2±24.6 °C

[ Exact Mass ]:
248.044189

[ PSA ]:
102.64000

[ LogP ]:
1.65

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.741

[ Stability ]:
Stable. Incompatible with acids, acid chlorides, acid anhydrides, chloroformates, strong oxidizing agents. Sensitive to air.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BX9580000
CHEMICAL NAME :
Aniline, p,p'-dithiodi-
CAS REGISTRY NUMBER :
722-27-0
LAST UPDATED :
199701
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C12-H12-N2-S2
MOLECULAR WEIGHT :
248.38
WISWESSER LINE NOTATION :
ZR DSSR DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
434 mg/kg/7D-I
TOXIC EFFECTS :
Endocrine - changes in adrenal weight Blood - pigmented or nucleated red blood cells Nutritional and Gross Metabolic - changes in iron

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
100 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 67,123,1979

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
BX9580000

[ Hazard Class ]:
9.0

[ HS Code ]:
2930909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Iodoaniline
  • 3-Aminothiophenol
  • 4-amino phenyl thiocyanate
  • 4-Aminothiophenol
  • 4-Chloronitrobenzene
  • 1-Fluoro-4-nitrobenzene
  • 1,2-Bis(4-nitrophenyl)disulfane
  • di(p-Nitrophenyl) sulfide
  • 4-Chloroaniline

DownStream

  • 1-isocyanato-4-[(4-isocyanatophenyl)disulfanyl]benzene
  • N-(4-sulfanylphenyl)benzamide
  • 1,4-BENZENEDITHIOL
  • 4-Acetamidothioanisole
  • 4,4'-Thiodianiline
  • Benzenamine,4-(phenylthio)-
  • 4-acetamidothiophenol
  • 4-Aminothiophenol
  • 4-Bromothiophenol
  • 1-(2-chloroethyl)-3-[4-[4-(2-chloroethylcarbamoylamino)phenyl]disulfanylphenyl]urea

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Elevated glutathione accelerates oxidative damage to erythrocytes produced by aromatic disulfide.

Blood 73(1) , 312-7, (1989)

It has been shown that certain dogs have erythrocytes characterized by an inherited high concentration of reduced glutathione (GSH), five to seven times the normal level (high-GSH RBCs). We examined w...

Kinetics of polymerization of hemoglobin S modified by thiol reagents and by oxidation.

Biochim. Biophys. Acta 830(1) , 71-9, (1985)

The effects of four thiol reagents on the kinetics of polymerization of hemoglobin S have been studied in high phosphate buffer (1.8 M), in the presence (3 mM) or absence of sodium dithionite, dependi...


More Articles

Related Compounds

  • Bis(3-fluoro-4-aminophenyl)disulfide
  • (4-aminophenyl)arsonous acid
  • [(4-aminophenyl)amino]methanedithioic acid
  • 4-Aminophenyl-beta-D-galactopyranoside
  • (4-aminophenyl) 3,4,5-tridodecoxybenzoate
  • [(4-aminophenyl)methylideneamino]urea
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
  • N-[3-(Aminooxy)propyl]-N-butyl-1-butanamine