Mevastatin

Suppliers

Names

[ Name ]:
Mevastatin

[Synonym ]:
ML 236B
Mevastatinum [INN-Latin]
mevastatin
Compactin (penicillium)
Antibiotic ML 236B
L66 AU IUTJ EOVY2&1 H1 G2- FT6OVTJ DQ &&stereoisomer
Mevastatin (Compactin)
MFCD05662341
Statin I
[(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
(+)-Compactin
ML 236 B
(1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-7-methyl-1,2,3,7,8,8a-hexahydro-1-naphthalenyl (2S)-2-methylbutanoate
Butanoic acid, 2-methyl-, (1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2S)-
2b-Methyl-8a-(2-methyl-1-oxobutoxy)mevinic acid lactone
ML-236B
(1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
7-[1,2,6,7,8,8a-Hexahydro-2-methyl-8-(methylbutyryloxy)naphthyl]-3-hydroxyheptan-5-olide
[1S-[1a(R*),7b,8b(2S*,4S*),8ab]]-2-Methylbutanoic acid 1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester
Compactin
Lovastatin Impurity 1

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
555.0±50.0 °C at 760 mmHg

[ Melting Point ]:
151-153 °C

[ Molecular Formula ]:
C₂₃H₃₄O₅

[ Molecular Weight ]:
390.513

[ Flash Point ]:
186.5±23.6 °C

[ Exact Mass ]:
390.240631

[ PSA ]:
72.83000

[ LogP ]:
3.57

[ Vapour Pressure ]:
0.0±3.4 mmHg at 25°C

[ Index of Refraction ]:
1.535

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: 20 mg/mL

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EK7907100

CHEMICAL NAME :: Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-7-methyl-8-(2-(tetrahydro-4-hy droxy-6-oxo-2H-pyran- 2-yl)ethyl)-1-naphthalenyl ester, (1S-(1-alpha(R*),7-beta,8-beta(2S*,4S*),8a-beta))-

CAS REGISTRY NUMBER :: 73573-88-3

LAST UPDATED :: 199212

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C23-H34-O5

MOLECULAR WEIGHT :: 390.57

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 29,1346,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 29,1346,1976

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
T+

[ Risk Phrases ]:
R26/27/28

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
EK7907100

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

(1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-((2R,4R)-tetrahydro-4-methoxy-6-oxo-2H-pyran-2-yl)-ethyl]-1-naphthyl (2S)-2-methylbutyrate
methyl 3,5-dihydroxy-7-[(1'S,2'S,8'S,8a'S)-2'methyl-8'-[(S)-2-methylbutanoyloxy]-1',2',3',7',8',8a'-hexahydro-1'-naphthyl]heptanoate
1β,4α-bis(benzyloxy)-1,2,3,4,4aβ,5,8,8aα-octahydronaphthalene
1β,4α-bis(benzyloxy)-7-oxo-1,2,3,4,4aβ,7,8,8aα-octahydronaphthalene
(+/-)-1,4,5,8,9,10-trans-hexahydronaphthalene-1,4-dione

DownStream

Pravastatin
Pravastatin (sodium)
Acetone
tert-Butanol

Articles

Endothelial protective genes induced by statin are mimicked by ERK5 activation as triggered by a drug combination of FTI-277 and GGTI-298.

Biochim. Biophys. Acta 1850 , 1415-25, (2015)

Statins are potent inhibitors of cholesterol biosynthesis and are clinically beneficial in preventing cardiovascular diseases, however, the therapeutic utility of these drugs is limited by myotoxicity...

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Chemical profiling and quantification of monacolins and citrinin in red yeast rice commercial raw materials and dietary supplements using liquid chromatography-accurate QToF mass spectrometry: Chemometrics application.

J. Pharm. Biomed. Anal. 100 , 243-53, (2014)

Red yeast rice (RYR) is prepared by fermenting rice with various strains of the yeast Monascus spp of the Aspergillaceae family. Depending on the Monascus strains and the fermentation conditions, the ...

mevastatin
Mevastatin Hydroxy Acid t-Butylamine Salt
N-[3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]phenyl]-N-methylacetamide
Cyclobutanemethanol, 3-methoxy-, 1-methanesulfonate
(4-Ethoxy-2,6-difluorophenyl)(methyl)sulfane
5-bromo-N-cyclopentyl-2-methoxy-4-Pyrimidinamine
Ethyl 3-(4-(cyclopentylamino)-2-methoxypyrimidin-5-yl)propanoate
Propanedioic acid,2-[1-(4-fluorophenyl)-1-methylethyl]-,1,3-dimethyl ester
1-methyl-4-propyl-1H-pyrazol-5-ol
3-(4-Amino-6-fluoro-1-oxo-isoindolin-2-yl)-3-methyl-piperidine-2,6-dione
4-[[(2R)-3,3-Diethyl-1-[[[(1S)-1-(4-methylphenyl)butyl]amino]carbonyl]-4-oxo-2-azetidinyl]oxy]benzeneacetic acid
Tert-butyl 3-bromo-1-(1-ethoxyethyl)-4,5-dihydropyrrolo[2,3-c]pyrazole-6(1h)-carboxylate

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.