1,4-Dianilinobenzene
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Names
[ CAS No. ]:
74-31-7
[ Name ]:
1,4-Dianilinobenzene
[Synonym ]:
1,4-Benzenediamine, N,N'-diphenyl-
1,4-benzenediamine, N1,N4-diphenyl-
1-N,4-N-diphenylbenzene-1,4-diamine
N,N'-Diphenyl-1,4-benzenediamine
p-phenylenediamine, N,N'-diphenyl-
dppd
N,N'-Diphenyl-1,4-phenylenediamine
n,n'-diphenylbenzene-1,4-diamine
1,4-Benzenediamine, N,N-diphenyl-
N,N′-Diphenyl-1,4-phenylenediamine
1,4-Dianilinobenzene
N,N′-Diphenyl-p-phenylenediamine
EINECS 200-806-4
n,n'-diphenyl-p-phenylenediamine
1,4-Bis(phenylamino)benzene
MFCD00003015
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
469.2±0.0 °C at 760 mmHg
[ Melting Point ]:
143-145 °C(lit.)
[ Molecular Formula ]:
C18H16N2
[ Molecular Weight ]:
260.333
[ Flash Point ]:
297.0±13.0 °C
[ Exact Mass ]:
260.131348
[ PSA ]:
24.06000
[ LogP ]:
3.32
[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C
[ Index of Refraction ]:
1.694
[ Stability ]:
Stable. Incompatible with strong acids, strong oxidizing agents
[ Water Solubility ]:
<0.1 g/100 mL at 20 ºC
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- ST2275000
- CHEMICAL NAME :
- p-Phenylenediamine, N,N'-diphenyl-
- CAS REGISTRY NUMBER :
- 74-31-7
- BEILSTEIN REFERENCE NO. :
- 2215944
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 18
- MOLECULAR FORMULA :
- C18-H16-N2
- MOLECULAR WEIGHT :
- 260.36
- WISWESSER LINE NOTATION :
- RMR DMR
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2370 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 18 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 182 gm/kg/2Y-C
- TOXIC EFFECTS :
- Liver - changes in liver weight Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 20443 mg/kg/3W-C
- TOXIC EFFECTS :
- Blood - change in clotting factors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1000 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 450 mg/kg
- SEX/DURATION :
- female 14 day(s) pre-mating female 1-22 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - parturition Reproductive - Effects on Newborn - stillbirth
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2500 mg/kg
- SEX/DURATION :
- female 1-22 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 4176 mg/kg
- SEX/DURATION :
- female 6-14 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)
MUTATION DATA
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 30 mg/L
- REFERENCE :
- SWEHDO Scandinavian Journal of Work, Environment and Health. (Haartmaninkatu 1, SF-00290 Helsinki, 29, Finland) V.1- 1975- Volume(issue)/page/year: 9(Suppl 2),27,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80282 No. of Facilities: 315 (estimated) No. of Industries: 5 No. of Occupations: 22 No. of Employees: 7496 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80282 No. of Facilities: 139 (estimated) No. of Industries: 4 No. of Occupations: 6 No. of Employees: 7680 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H317-H412
[ Precautionary Statements ]:
P273-P280
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R43;R52/53
[ Safety Phrases ]:
S24-S37-S61
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
1
[ RTECS ]:
ST2275000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1
[ HS Code ]:
2921590090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2921590090
[ Summary ]:
2921590090. other aromatic polyamines and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
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p-Phenylenediamine (PPD)-related chemicals have been used as antioxidants in rubber products, and many cases of contact dermatitis caused by these chemicals have been reported.The aim of this study wa...
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