Ethambutol

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Names

[ CAS No. ]:
74-55-5

[ Name ]:
Ethambutol

[Synonym ]:
(S,S)-Et,Et-FerroTANE
(+)-1,1'-BIS[(2R,4R)-2,4-DIETHYLPHOSPHONATO]FERROCENE
R,R-Et-FerroTANE
(S,S)-2,2'-(ethylenediimino)di-1-butanol
(R,R)-ET-FERROTANE(TM)
(+)-1,1'-BIS((2R,4R)-2,4-DIETHYLPHOSPHOTANO)FERROCENE
(S,S)-1-[1-(DI-TERT-BUTYLPHOSPHINO)ETHYL]-2-(DIPHENYLPHOSPHINO)FERROCENE
Et-Ferrotane
1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-
Ethambutol
(S)-(+)-1-[(R)-2-(DIPHENYLPHOSPHINO)FERROCENYL]ETHYLDI-T-BUTYLPHOSPHINE
2,2'-(1,2-Ethanediyldiimino)di(1-butanol)
JOSIPHOS SL-J002-2

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
345.3±22.0 °C at 760 mmHg

[ Melting Point ]:
199 - 204ºC

[ Molecular Formula ]:
C₁₀H₂₄N₂O₂

[ Molecular Weight ]:
204.310

[ Flash Point ]:
113.7±12.9 °C

[ Exact Mass ]:
204.183777

[ PSA ]:
64.52000

[ LogP ]:
-0.05

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.478

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EL3640000

CHEMICAL NAME :: 1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, (R)-

CAS REGISTRY NUMBER :: 74-55-5

LAST UPDATED :: 199706

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C10-H24-N2-O2

MOLECULAR WEIGHT :: 204.36

WISWESSER LINE NOTATION :: Q1Y2&M2MY2&1Q -D

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 900 mg/kg/60D-I

TOXIC EFFECTS :: Liver - jaundice, cholestatic

REFERENCE :: BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 292,866,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - structural change in nerve or sheath Behavioral - changes in motor activity (specific assay) Kidney, Ureter, Bladder - other changes in urine composition

REFERENCE :: BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 2,1105,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Skin and Appendages - dermatitis, other (after systemic exposure) Immunological Including Allergic - anaphylaxis

REFERENCE :: BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 2,1105,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8700 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. (Warsaw, Poland) V.18-24, 1966-72. For publisher information, see PJPPAA. Volume(issue)/page/year: 23,463,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1075 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. (Warsaw, Poland) V.18-24, 1966-72. For publisher information, see PJPPAA. Volume(issue)/page/year: 23,463,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 240 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. (Warsaw, Poland) V.18-24, 1966-72. For publisher information, see PJPPAA. Volume(issue)/page/year: 23,463,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 890 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 63(3),114S,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 63(3),114S,1967

Safety Information

[ HS Code ]:
2922191000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

(2S,2'S)-(ethylenediimino)-bis(3-buten-1-yl)benzyl ether
(2S,2'S)-(oxalamido)-bis(3-buten-1-yl)benzyl ether
N,N'-bis[(2S)-1-[tert-butyl(dimethyl)silyl]oxybutan-2-yl]oxamide
(-)-(S)-N,N'-Bis-(2-hydroxy-1-aethyl-aethyl)-oxalsaeurediamid
2,2'-bis(4-ethyloxazoline)
N,N'-bis-((S)-1-chloromethyl-propyl)-oxalamide
Isobutanol-2-amine
dichloroethane
1,2-Dibromoethane

DownStream

Customs

[ HS Code ]: 2922191000

Related Compounds

Ethambutol
ethambutol
ethambutol
ethambutol
Ethambutol-d4
EthaMbutol-d8
4,4-difluoro-1-(1-phenyl-1H-pyrazol-4-yl)cyclohexan-1-amine
[1-(2-Phenoxyphenyl)cyclopropyl]methanol
2-Methyl-2-(2-phenoxyphenyl)propan-1-amine
4,4-difluoro-1-(3-phenyl-1H-pyrazol-4-yl)cyclohexan-1-amine
Methyl 3-(4,5-difluoro-2-methoxyphenyl)-3-oxopropanoate
3-(2,6-Difluorophenyl)-2,2-dimethylcyclopropane-1-carboxylic acid
5-Methoxy-5-oxo-3-(pyridin-4-yl)pentanoic acid
(1S)-3-amino-1-(5-methyl-2-nitrophenyl)propan-1-ol
3-(5-Methyl-2-nitrophenyl)azetidine
1-[2-(Pyrazin-2-yl)propan-2-yl]cyclopropan-1-amine

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