Prostaglandin F1α
Suppliers
Names
[ CAS No. ]:
745-62-0
[ Name ]:
Prostaglandin F1α
[Synonym ]:
protaglandinf1
prostaglandin F1alpha
PGF1ALPHA
PGF1
(9α,11α,13E,15S)-9,11,15-Trihydroxyprost-13-en-1-oic acid
EINECS 234-237-8
PROSTAGLANDIN F1A
Prostaglandin F1α
prostaglandinf1
PROSTAGLANDINS F1ALPHA
syntheticwhitecrystallinesolid
MFCD00077862
Prost-13-en-1-oic acid, 9,11,15-trihydroxy-, (9α,11α,13E,15S)-
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
526.5±50.0 °C at 760 mmHg
[ Molecular Formula ]:
C20H36O5
[ Molecular Weight ]:
356.497
[ Flash Point ]:
286.3±26.6 °C
[ Exact Mass ]:
356.256287
[ PSA ]:
97.99000
[ LogP ]:
2.60
[ Vapour Pressure ]:
0.0±3.1 mmHg at 25°C
[ Index of Refraction ]:
1.555
[ Storage condition ]:
-20°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GY4569700
- CHEMICAL NAME :
- Cyclopentaneheptanoic acid, 3,5-dihydroxy-2-(3-hydroxy-1-octenyl)-
- CAS REGISTRY NUMBER :
- 745-62-0
- LAST UPDATED :
- 198910
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C20-H36-O5
- MOLECULAR WEIGHT :
- 356.56
- WISWESSER LINE NOTATION :
- L5TJ AQ B6VQ C1U1YQ5 DQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 150 mg/kg
- SEX/DURATION :
- female 4-6 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - other measures of fertility
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 1 mg/kg
- SEX/DURATION :
- female 12-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 45 mg/kg
- SEX/DURATION :
- male 15 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 10 mg/kg
- SEX/DURATION :
- female 16 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 3 mg/kg
- REFERENCE :
- INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year: 21,82,1976
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Safety Phrases ]:
S22-S24/25
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
GY4569700
Articles
Biochim. Biophys. Acta 620(3) , 352-5, (1980)
We investigated in vitro the influence of low density lipoprotein (LDL) cholesterol and high density lioprotein (HDL) cholesterol separated from human serum on prostaglandin I2 synthetase activity stu...
Atherosclerosis 184(1) , 48-52, (2006)
Inflammation is pivotal in atherogenesis. Numerous prospective studies have shown that levels of high sensitive C-reactive protein (CRP) predict cardiovascular events. Recently, data suggests that CRP...
Cardiovasc. Res. 75(2) , 398-407, (2007)
Experimental studies and opinion articles emphasize that cardiovascular alterations associated with ageing can be improved by the long-term use of fenofibrates. We analyzed the effect of fenofibrate t...