Acetamide,2-hydroxy-N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-

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Names

[ CAS No. ]:
74515-40-5

[ Name ]:
Acetamide,2-hydroxy-N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-

[Synonym ]:
Acetamide,2-hydroxy-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-,(S)
2-hydroxy-n-(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide
Colchifoline
N-(2-hydroxyacetyl)deacetylcolchicine

Chemical & Physical Properties

[ Density]:
1.31g/cm3

[ Boiling Point ]:
768.9ºC at 760 mmHg

[ Molecular Formula ]:
C22H25NO7

[ Molecular Weight ]:
415.43600

[ Flash Point ]:
418.8ºC

[ Exact Mass ]:
415.16300

[ PSA ]:
103.32000

[ LogP ]:
2.23490

[ Index of Refraction ]:
1.601

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AC4010000
CHEMICAL NAME :
Acetamide, 2-hydroxy-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy -9-oxobenzo(a)heptale n- 7-yl)-, (S)-
CAS REGISTRY NUMBER :
74515-40-5
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C22-H25-N-O7
MOLECULAR WEIGHT :
415.48
WISWESSER LINE NOTATION :
T B677 MV&T&J CO1 DO1 EO1 JMV1Q NO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1620 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 26,1365,1983

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Glycolic acid
  • Trimethylcolchicinic acid methyl ether
  • Colchicine
  • N-Boc-colchicine

DownStream

Related Compounds

  • 1'-Methyl-1'H-spiro[piperidine-3,2'-quinazolin]-4'(3'H)-one
  • 2-[4-(Difluoromethoxy)phenyl]-2-methylpropan-1-amine
  • 1'-Ethyl-1'H-spiro[piperidine-3,2'-quinazolin]-4'(3'H)-one
  • 2-(2-Chloro-6-fluorophenyl)propan-2-amine
  • 6'-Fluoro-1'H-spiro[piperidine-3,2'-quinazolin]-4'(3'H)-one
  • (3aR,7S,7aR)-tert-butyl 5-(3-aminopyridin-4-yl)-7-methyl-2-oxohexahydrooxazolo[4,5-c]pyridine-3(2H)-carboxylate
  • 6'-Fluoro-1'-methyl-1'H-spiro[piperidine-3,2'-quinazolin]-4'(3'H)-one
  • 5-Methyl-3-(3-nitropyridin-4-yl)cyclohex-2-enol
  • 1'-Ethyl-6'-fluoro-1'H-spiro[piperidine-3,2'-quinazolin]-4'(3'H)-one
  • tert-butyl-dimethyl-[(1R,5R)-5-methyl-3-(3-nitropyridin-4-yl)cyclohex-2-en-1-yl]oxysilane
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