2-Cyanobenzaldehyde

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Names

[ CAS No. ]:
7468-67-9

[ Name ]:
2-Cyanobenzaldehyde

[Synonym ]:
o-Cyanobenzaldehyde
2-cyanobenzaldehyde
2-Formylbenzonitrile
MFCD00017503
Benzonitrile, 2-formyl-
2-Formylbenzolcarbonitril

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
284.9±23.0 °C at 760 mmHg

[ Melting Point ]:
103-105 °C(lit.)

[ Molecular Formula ]:
C8H5NO

[ Molecular Weight ]:
131.131

[ Flash Point ]:
126.1±22.6 °C

[ Exact Mass ]:
131.037109

[ PSA ]:
40.86000

[ LogP ]:
1.45

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.552

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H315-H319-H332-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S26-S37/39-S36/37/39

[ RIDADR ]:
UN 3439 6.1/PG 3

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2926909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Cyanophenylboronic Acid
  • carbon monoxide
  • 2-(dibromomethyl)benzonitrile
  • 2-Cyanobenzyl bromide
  • 2-Bromobenzonitrile
  • o-Phthalaldehyde
  • o-Tolunitrile
  • zinc,dicyanide

DownStream

  • (1Z)-1-[(4-methoxyphenyl)imino]-1H-isoindol-3-amine
  • 2-Cyanobenzoic acid
  • 2-Ethynylaniline
  • (2-(Aminomethyl)phenyl)methanol
  • Isoquinoline-1,3(2H,4H)-dione
  • Benzoic acid, 2-cyano-,ethyl ester
  • Methyl 2-cyanobenzoate
  • Phenylisoquinoline
  • 2-Benzothiazol-2-yl-benzonitrile
  • 1(3H)-Isobenzofuranone,3-phenyl-

Customs

[ HS Code ]: 2926909090

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Diastereoselective one-pot tandem synthesis of 3-substituted isoindolinones: a mechanistic investigation.

J. Org. Chem. 75(17) , 5882-7, (2010)

The mechanism of a base-catalyzed one-pot reaction of 2-cyanobenzaldehyde and primary nitroalkanes, to produce 3-substituted isoindolinones, has been investigated. A route starting with a nitroaldol (...

Bifunctional phase-transfer catalysis in the asymmetric synthesis of biologically active isoindolinones.

Beilstein J. Org. Chem. 11 , 2591-9, (2015)

New bifunctional chiral ammonium salts were investigated in an asymmetric cascade synthesis of a key building block for a variety of biologically relevant isoindolinones. With this chiral compound in ...

The aldol addition of readily enolizable 1, 3-dicarbonyl compounds to 2-cyanobenzaldehyde in the synthesis of novel 3-substituted isoindolinones. More V, et al.

Synthesis 2011(18) , 3027-31, (2011)


More Articles

Related Compounds

  • 2-cyanobenzaldehyde oxime
  • 4-Bromo-2-cyanobenzaldehyde
  • 5-chloro-2-cyanobenzaldehyde
  • 4-chloro-2-cyanobenzaldehyde
  • 3-Chloro-2-cyanobenzaldehyde
  • 2-isopropoxy-5-cyanobenzaldehyde
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1-Acetyl-1-azaspiro[3.3]heptane-6-carboxylic acid
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • 3-[(2,2-Dimethylthiolan-3-yl)oxy]azetidine
  • 1-(3-Methylidenecyclopentyl)methanamine hydrochloride
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde