Cloricromenehydrochloride

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Names

[ CAS No. ]:
74697-28-2

[ Name ]:
Cloricromenehydrochloride

[Synonym ]:
AD6
Cloricromen hydrochloride
Proendotel (TN)
8-Chloro-3-(2-diethylaminoethyl)-7-ethoxycarbonylmethoxy-4-methylcoumarin hydrochloride
Cloricromen hydrohloride

Chemical & Physical Properties

[ Boiling Point ]:
538ºC at 760 mmHg

[ Melting Point ]:
221-222.3ºC

[ Molecular Formula ]:
C20H27Cl2NO5

[ Molecular Weight ]:
432.33800

[ Flash Point ]:
279.2ºC

[ Exact Mass ]:
431.12700

[ PSA ]:
68.98000

[ LogP ]:
4.38300

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
22

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
AF8970000

Articles

Cloricromene in endotoxemia: role of NF-kappaB.

Naunyn Schmiedebergs Arch. Pharmacol. 370(2) , 140-5, (2004)

In this study we investigated, for the first time in vivo, the effect of cloricromene, a cumarine derivative, on NF-kappaB activation in endotoxin-treated rats. Endotoxemia was induced in male rats by...

Tumor necrosis factor induces E-selectin production in splanchnic artery occlusion shock.

Am. J. Physiol. 268(4 Pt 2) , H1412-7, (1995)

Splanchnic arteries were clamped for 45 min to induce splanchnic artery occlusion (SAO) shock in anesthetized rats. Sham-operated animals were used as controls. Survival time, serum tumor necrosis fac...

Preparation and characterization of eudragit retard nanosuspensions for the ocular delivery of cloricromene.

AAPS PharmSciTech 7(1) , E27, (2006)

The purpose of this study was to improve the stability of cloricromene (AD6) in ophthalmic formulations and its drug availability at the ocular level. To this end, AD6-loaded polymeric nanoparticle su...


More Articles

Related Compounds

  • 1-(2-{[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)ethyl]sulfanyl}acetyl)-4-methoxypyrrolidine-3-carboxylic acid
  • 2-(1-{5-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]-1,2-oxazole-3-carbonyl}azetidin-3-yl)acetic acid
  • 2-[5-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanamido]-5-methylhexanoic acid
  • 2-{2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]-3-methylbutanamido}-5-methylhexanoic acid
  • 2-[(2R,3S)-3-(benzyloxy)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]-6-chlorobenzoic acid
  • 4-{3-[benzyl(methyl)amino]-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoyl}thiomorpholine-2-carboxylic acid
  • 2-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-hydroxybutanoyl]-octahydrocyclopenta[c]pyrrole-1-carboxylic acid
  • 2-{4-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutanecarbonyl]piperazin-1-yl}propanoic acid
  • 2-[2-cyclopropyl-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoyl]-2-azabicyclo[2.1.1]hexane-1-carboxylic acid
  • Tert-butyl 2-[3-(difluoromethoxy)phenyl]piperazine-1-carboxylate
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