Chrysene, 6-nitro-

Names

[ CAS No. ]:
7496-02-8

[ Name ]:
Chrysene, 6-nitro-

[Synonym ]:
6-nitrochrysene
MFCD00021179

Chemical & Physical Properties

[ Density]:
1.342g/cm3

[ Boiling Point ]:
505ºC at 760 mmHg

[ Melting Point ]:
220ºC (dec.)(lit.)

[ Molecular Formula ]:
C₁₈H₁₁NO₂

[ Molecular Weight ]:
273.28500

[ Flash Point ]:
252.5ºC

[ Exact Mass ]:
273.07900

[ PSA ]:
45.82000

[ LogP ]:
5.57760

[ Index of Refraction ]:
1.791

[ Storage condition ]:
2-8°C

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GC1930000

CHEMICAL NAME :: Chrysene, 6-nitro-

CAS REGISTRY NUMBER :: 7496-02-8

BEILSTEIN REFERENCE NO. :: 2134652

LAST UPDATED :: 199612

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C18-H11-N-O2

MOLECULAR WEIGHT :: 273.30

WISWESSER LINE NOTATION :: L E6 B666J DNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9163 ug/kg/2W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 10 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 279,153,1992 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 46,267,1989 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 46,267,1989 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 46,267,1989

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302 + H312 + H332-H340-H350

[ Precautionary Statements ]:
P201-P261-P280-P301 + P312 + P330-P308 + P313

[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T

[ Risk Phrases ]:
45-46-20/21/22

[ Safety Phrases ]:
S22;S45;S53;S36/S37/S39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
GC1930000

Precursor & DownStream

Precursor

DownStream

6-Aminochrysene
chrysen-6-ol
6,12-dinitrochrysene
chrysen-6-yl acetate

Articles

Polycyclic nitroarenes (nitro-PAHs) as biomarkers of exposure to diesel exhaust.

Mutat. Res. 441(1) , 135-44, (1999)

Diesel exhaust contains numerous genotoxic carcinogens. It is essentially unknown to which extent this source contributes to the total load of these chemicals in humans. One possible approach to the p...

Synthesis of anti-1,2-dihydroxy-3,4-epoxy-1,2,3, 4-tetrahydro-6-nitrochrysene and its reaction with 2'-deoxyguanosine- 5'-monophosphate, 2'-deoxyadenosine-5'-monophosphate, and calf thymus DNA in vitro.

Chem. Res. Toxicol. 13(11) , 1143-8, (2000)

The remarkable carcinogenic activity of 6-nitrochrysene (6-NC) in several animal models, and its environmental presence, suggest its potential importance with regard to human cancer development. Depen...

Genomic DNA sequencing of mRNA splicing mutants in the hprt gene of Chinese hamster ovary cells.

Environ. Mol. Mutagen. 25(2) , 85-96, (1995)

We have analyzed 41 mRNA-splicing mutants from the hypoxanthine-guanine phosphoribosyl-transferase (hprt) gene of Chinese hamster ovary (CHO) cells. Twenty-two of these mutants produced single cDNA PC...

Dibenzo[def,mno]chrysene, 6-nitro-
nitric acid,(7-oxo-1,8-naphthyridin-8-id-2-yl)azanide,2-piperidin-1-id-2-ylpiperidin-1-ide,6-piperidin-1-id-2-yl-2H-pyridin-1-ide,platinum
CHRYSENE, 5-METHYL-6-NITRO-
Chrysene, 6-fluoro-
4-(6-Nitro-quinoxalin-2-ylaMino)-piperidine-1-carboxylic acid tert-butyl ester
N-((6-Nitro-1H-benzimidazol-1-yl)methyl)benzamide
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
2-(3-Chloro-2-methoxyphenyl)-2-methoxypropan-1-amine
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide