2-Chloropropane

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Names

[ CAS No. ]:
75-29-6

[ Name ]:
2-Chloropropane

[Synonym ]:
isopropylchloride
MFCD00000859
2-Propylchloride
iso-C3H7Cl
Narcosop
2-chloro-propan
i-propyl chloride
Propane-2-chloro
Isoprid
2-CHLOROPROPENE
EINECS 209-187-5
2-monochloropropane
2-Chlorpropan
R280da

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
37.3±8.0 °C at 760 mmHg

[ Melting Point ]:
-118 °C

[ Molecular Formula ]:
C3H7Cl

[ Molecular Weight ]:
78.541

[ Flash Point ]:
-35.0±0.0 °C

[ Exact Mass ]:
78.023628

[ LogP ]:
1.85

[ Vapour Pressure ]:
488.8±0.1 mmHg at 25°C

[ Index of Refraction ]:
1.379

[ Stability ]:
Stable. Incompatible with strong oxidizing agents, strong bases. Highly flammable - note low flash point. Cool to zero C before opening.

[ Water Solubility ]:
3.1 g/L (20 ºC)

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TX4410000
CHEMICAL NAME :
Propane, 2-chloro-
CAS REGISTRY NUMBER :
75-29-6
BEILSTEIN REFERENCE NO. :
1730782
LAST UPDATED :
199710
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C3-H7-Cl
MOLECULAR WEIGHT :
78.55

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
120 gm/m3
TOXIC EFFECTS :
Blood - changes in leukocyte (WBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1300 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
119 gm/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
236 gm/m3/30M/1W-I
TOXIC EFFECTS :
Liver - other changes

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
1 gm/plate
REFERENCE :
DTESD7 52 Vanderbilt Ave., New York, NY 10017) V.1-15, 1977-87. Discontinued 52 Vanderbilt Ave., New York, NY 10017) V.1- 1977- Volume(issue)/page/year: 2,249,1977 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5379 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 145 (estimated) No. of Female Employees: 3 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H224-H290-H302 + H312 + H332

[ Precautionary Statements ]:
P210-P261-P301 + P312 + P330-P302 + P352 + P312-P304 + P340 + P312-P403 + P235

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)

[ Hazard Codes ]:
F:Flammable;Xn:Harmful;

[ Risk Phrases ]:
R11;R20/21/22

[ Safety Phrases ]:
S9-S29

[ RIDADR ]:
UN 2456 3/PG 1

[ WGK Germany ]:
3

[ RTECS ]:
UC7200000

[ Packaging Group ]:
I

[ Hazard Class ]:
3

[ HS Code ]:
2903199000

Synthetic Route

Precursor & DownStream

Precursor

  • propene
  • Isopropanol
  • Isopropyl ether
  • Triisopropyl phosphite
  • 2-(Chloromethoxy)ethyl acetate
  • Propane Residual Solvent Standard
  • Bromotrichloromethane
  • carbon monoxide
  • isopropyloxy(diphenyl)-λ6-sulfanenitrile
  • 2-Methylpropanoyl chloride

DownStream

  • 1,1,2-TRICHLOROPROPANE
  • 2,6-lutidine
  • 3-Acetyl-2,6-lutidine
  • 3-Acetyl-2,4,6-trimethylpyridine
  • 1-(5-acetyl-2,6-dimethylpyridin-3-yl)ethanone
  • 2,4,6-Trimethylpyridine
  • 3-isopropyl-4-methoxybenzaldehyde
  • HYDROGEN CYANIDE
  • Cyanogen chloride
  • Isopropyl Dimethyl Chlorosilane

Customs

[ HS Code ]: 2903199000

[ Summary ]:
2903199000 other saturated chlorinated derivatives of acyclic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%


Related Compounds

  • 2-chloropropane-d3
  • 2-Chloropropane-d7
  • 2-Chloropropane-d7
  • 2-chloropropane-2-d1
  • 2-BROMO-2-CHLOROPROPANE
  • 1-bromo-2-chloropropane