LOVASTATIN HYDROXY ACID, SODIUM SALT

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Names

[ CAS No. ]:
75225-51-3

[ Name ]:
LOVASTATIN HYDROXY ACID, SODIUM SALT

[Synonym ]:
2-methoxy-4,4'-dihydroxychalcone
Echinantin
4',4-dihydroxy-2-methoxychalcone
LOVASTATIN HYDROXY ACID, SODIUM SALT
Echinatin
Mevinolinic acid
lovastatin acid
loureirin C
lovastatin hydroxy acid

Chemical & Physical Properties

[ Density]:
1.14g/cm3

[ Boiling Point ]:
602.3ºC at 760 mmHg

[ Molecular Formula ]:
C24H38O6

[ Molecular Weight ]:
422.55

[ Flash Point ]:
199.1ºC

[ Exact Mass ]:
447.26800

[ PSA ]:
106.89000

[ LogP ]:
2.38090

[ Index of Refraction ]:
1.537

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QJ7180000
CHEMICAL NAME :
1-Naphthaleneheptanoic aicd, 1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimet hyl-8- (2-methyl-1-oxobutoxy)-, ammonium salt, (1S-(1-alpha(beta-S*,delta-S*),2-alpha,6-beta, 8-beta(R*),8a-beta))-
CAS REGISTRY NUMBER :
75225-51-3
LAST UPDATED :
198910
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C24-H38-O6.H3-N
MOLECULAR WEIGHT :
439.66

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
749 mg/kg
SEX/DURATION :
female 6-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 28,449,1983

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Lovastatin
  • monacolin J acid
  • α-S-methylbutyryl-CoA
  • (S)-2-methylbutyric acid

DownStream

  • Lovastatin

Related Compounds

  • Epi Lovastatin Hydroxy Acid Sodium Salt
  • DES (2-METHYLBUTYRATE) LOVASTATIN HYDROXY ACID SODIUM SALT
  • Lovastatin hydroxy acid sodium
  • Simvastatin Hydroxy Acid Sodium Salt
  • Epi Lovastatin Hydroxy Acid-d3 sodium salt
  • 2,3-Difluorobenzaldehyde
  • rac-(1R,2S)-2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methylpropanamido]cyclohexane-1-carboxylic acid
  • rac-(1R,2S)-2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pent-4-ynamido]cyclohexane-1-carboxylic acid
  • (1RS,2SR)-2-[(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pentanamido]cyclohexane-1-carboxylic acid
  • (1RS,2SR)-2-[(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylbutanamido]cyclohexane-1-carboxylic acid
  • 4-{1-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-1-methyl-1H-pyrazol-4-yl]-N-methylformamido}butanoic acid
  • 5-{[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-1-methyl-1H-pyrazol-4-yl]formamido}pentanoic acid
  • 3-{[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-1-methyl-1H-pyrazol-4-yl]formamido}propanoic acid
  • 2-{N-ethyl-1-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-1-methyl-1H-pyrazol-4-yl]formamido}acetic acid
  • 1-[(2S,3R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methoxybutanoyl]-4,4-difluoropyrrolidine-3-carboxylic acid
  • 2-[(2S,3R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methoxybutanoyl]-4-methyl-2-azabicyclo[2.1.1]hexane-1-carboxylic acid
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