LOVASTATIN HYDROXY ACID, SODIUM SALT

Modify Date: 2025-08-25 20:56:26

LOVASTATIN HYDROXY ACID, SODIUM SALT structure	Common Name	LOVASTATIN HYDROXY ACID, SODIUM SALT
	CAS Number	75225-51-3	Molecular Weight	422.55
	Density	1.14g/cm3	Boiling Point	602.3ºC at 760 mmHg
	Molecular Formula	C₂₄H₃₈O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	199.1ºC

Use of LOVASTATIN HYDROXY ACID, SODIUM SALT

Lovastatin acid (Mevinolinic acid), an active metabolite of Lovastatin, is a potent competitive HMG-CoA reductase inhibitor with a Ki of 0.6 nM[1].

Name	mevinolinic acid
Synonym	More Synonyms

Description	Lovastatin acid (Mevinolinic acid), an active metabolite of Lovastatin, is a potent competitive HMG-CoA reductase inhibitor with a Ki of 0.6 nM[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR)
Target	Ki: 0.6 nM (HMG-CoA reductase)[1]
References	[1]. Alberts AW, et al. Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc Natl Acad Sci U S A. 1980 Jul;77(7):3957-61.

Density	1.14g/cm3
Boiling Point	602.3ºC at 760 mmHg
Molecular Formula	C₂₄H₃₈O₆
Molecular Weight	422.55
Flash Point	199.1ºC
Exact Mass	447.26800
PSA	106.89000
LogP	2.38090
Index of Refraction	1.537

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ7180000

CHEMICAL NAME :: 1-Naphthaleneheptanoic aicd, 1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimet hyl-8- (2-methyl-1-oxobutoxy)-, ammonium salt, (1S-(1-alpha(beta-S*,delta-S*),2-alpha,6-beta, 8-beta(R*),8a-beta))-

CAS REGISTRY NUMBER :: 75225-51-3

LAST UPDATED :: 198910

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C24-H38-O6.H3-N

MOLECULAR WEIGHT :: 439.66

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 749 mg/kg

SEX/DURATION :: female 6-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 28,449,1983

Lovastatin

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LOVASTATIN HYDR...

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(4R,6R)-4-hydro...

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monacolin J acid

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Literature: DIVERSA CORPORATION Patent: WO2005/40107 A2, 2005 ; Location in patent: Page/Page column 77-80 ;

Lovastatin

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LOVASTATIN HYDR...

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Literature: Nagasawa, Kazuki; Muraki, Yuichi; Matsuda, Tomoko; Ohnishi, Noriaki; Yokoyama, Teruyoshi Journal of Pharmaceutical Sciences, 2000 , vol. 89, # 12 p. 1594 - 1604

monacolin J acid

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LOVASTATIN HYDR...

CAS#:75225-51-3

Literature: Xie, Xinkai; Meehan, Michael J.; Xu, Wei; Dorrestein, Pieter C.; Tang, Yi Journal of the American Chemical Society, 2009 , vol. 131, p. 8388 - 8389

α-S-methylbutyr...

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monacolin J acid

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LOVASTATIN HYDR...

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Literature: Xie, Xinkai; Meehan, Michael J.; Xu, Wei; Dorrestein, Pieter C.; Tang, Yi Journal of the American Chemical Society, 2009 , vol. 131, p. 8388 - 8389

N/A

CAS#:945630-22-8

monacolin J acid

CAS#:132748-10-8

LOVASTATIN HYDR...

CAS#:75225-51-3

Literature: Xie, Xinkai; Meehan, Michael J.; Xu, Wei; Dorrestein, Pieter C.; Tang, Yi Journal of the American Chemical Society, 2009 , vol. 131, p. 8388 - 8389

(S)-2-methylbut...

CAS#:1730-91-2

monacolin J acid

CAS#:132748-10-8

LOVASTATIN HYDR...

CAS#:75225-51-3

Literature: Xie, Xinkai; Meehan, Michael J.; Xu, Wei; Dorrestein, Pieter C.; Tang, Yi Journal of the American Chemical Society, 2009 , vol. 131, p. 8388 - 8389

Precursor 4
CAS#:75330-75-5 Lovastatin CAS#:132748-10-8 monacolin J acid CAS#:87069-91-8 α-S-methylbutyr... CAS#:1730-91-2 (S)-2-methylbut...
DownStream 1
CAS#:75330-75-5 Lovastatin

2-methoxy-4,4'-dihydroxychalcone

Echinantin

4',4-dihydroxy-2-methoxychalcone

LOVASTATIN HYDROXY ACID, SODIUM SALT

Echinatin

Mevinolinic acid

lovastatin acid

loureirin C

lovastatin hydroxy acid

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