Boc-L-aspartic acid 4-benzyl ester

Suppliers

Names

[ Name ]:
Boc-L-aspartic acid 4-benzyl ester

[Synonym ]:
(2S)-4-(benzyloxy)-2-[(tert-butoxycarbonyl)amino]-4-oxobutanoic acid (non-preferred name)
EINECS 231-406-8
N-tert-Butoxycarbonyl-L-aspartic acid 4-benzyl ester
MFCD00065564
(2S)-4-(Benzyloxy)-2-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)-4-oxobutanoic acid
(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-4-oxo-4-phenylmethoxybutanoic acid
L-Aspartic acid, N-((1,1-dimethylethoxy)carbonyl)-, 4-(phenylmethyl) ester
L-Aspartic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 4-(phenylmethyl) ester
N-α-t-BOC-L-aspartic-β-benzyl ester
Boc-Asp(OBzl)-OH
Boc-L-asparticacid4-benzylester

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
508.1±50.0 °C at 760 mmHg

[ Melting Point ]:
98-102ºC

[ Molecular Formula ]:
C₁₆H₂₁NO₆

[ Molecular Weight ]:
323.341

[ Flash Point ]:
261.1±30.1 °C

[ Exact Mass ]:
323.136902

[ PSA ]:
101.93000

[ LogP ]:
3.24

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.527

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Di-tert-butyl dicarbonate
H-Asp(OBzl)-OH
α-picolyl N-Boc-L-aspartate(OBn)
L-Aspartic acid dibenzyl ester 4-toluenesulfonate
p-Toluenesulfonic acid
(S)-TERT-BUTYL (2,5-DIOXOTETRAHYDROFURAN-3-YL)CARBAMATE
Benzyl alcohol

DownStream

L-Aspartic acid
Boc-Asp-OtBu
Boc-Cholecystokinin Octapeptide (3-8)
(3S)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-hydroxybutanoic acid
2-Methyl-2-propanyl N-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-homoserinate
Boc-L-Asp(Bzl)-ONp
Boc-Dap(Z)-OH
Boc-L-aspartic acid 4-methyl ester
HL-Asp(Bzl)-OBzl * HCl
(S)-3-Boc-Amino-gamma-butyrolactone

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Vitamin K1 dependent carboxylase: beta-carboxylation of t-butyloxycarbonylaspartic acid alpha-benzyl ester.

Biochem. Biophys. Res. Commun. 107(1) , 246-9, (1982)

Vitamin K-dependent carboxylase. Carboxylation of aspartyl residues to beta-carboxyaspartyl residues in synthetic substrates.

J. Biol. Chem. 259(7) , 4272-8, (1984)

The rat liver microsomal vitamin K-dependent carboxylase has been shown to carboxylate the aspartyl residue in N alpha-t-butyloxycarbonylaspartic acid alpha-benzyl ester to a beta-carboxyaspartyl resi...

Transesterification and amide cis-trans isomerization in Zn and Cd complexes of the chelating amino acid ligand Boc-Asp(Dpa)-OBzl.

Dalton Trans. (1) , 154-62, (2007)

The amino acid derivative Boc-Asp-OBzl (Boc=N-butyloxycarbonyl; Asp=aspartic acid; Bzl=benzyl) was functionalized by coupling its carboxylate side chain to dipicolylamine. This yielded the tridentate ...