Fludarabine phosphate
Suppliers
Names
[ CAS No. ]:
75607-67-9
[ Name ]:
Fludarabine phosphate
[Synonym ]:
2-Fluoro-9-(5-O-phosphono-β-D-arabinofuranosyl)-9H-purin-6-amine
2-fluoro-araamp
Fludara
Fludarabin Phosphate
Fludarabine (phosphate)
2-fluoro-ara-C-5'-O-phosphate
2-Fluoroadenine arabinoside 5'-monophosphate
fludarabinemonophosphate
Fludarabine 5'-Phosphate
fludarabine hcl
fludarabine monophosphate
Fludura
Fludarabine Phosphate (Fludara)
Fludarabine 5'-monophosphate
Fludarabine phosphate
fludarabine
9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-β-D-arabinofuranosyl)-
FLUDARUBINE PHOSPHATE
[(2R,3S,4S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen phosphate
F-ara-AMP
FAMP
MFCD00866418
Chemical & Physical Properties
[ Density]:
2.4±0.1 g/cm3
[ Boiling Point ]:
864.2±75.0 °C at 760 mmHg
[ Melting Point ]:
203 °C(dec.)
[ Molecular Formula ]:
C10H13FN5O7P
[ Molecular Weight ]:
365.212
[ Flash Point ]:
476.4±37.1 °C
[ Exact Mass ]:
365.053650
[ PSA ]:
195.88000
[ LogP ]:
0.41
[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C
[ Index of Refraction ]:
1.879
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UO7440900
- CHEMICAL NAME :
- 9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-
- CAS REGISTRY NUMBER :
- 75607-67-9
- LAST UPDATED :
- 198910
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C10-H13-F-N5-O7-P
- MOLECULAR WEIGHT :
- 365.25
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - child
- DOSE/DURATION :
- 18750 mg/kg/5D-I
- TOXIC EFFECTS :
- Brain and Coverings - encephalitis Sense Organs and Special Senses (Eye) - visual field changes
- REFERENCE :
- CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 70,1225,1986
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 17760 mg/kg/5D-I
- TOXIC EFFECTS :
- Brain and Coverings - demyelination Behavioral - hallucinations, distorted perceptions Behavioral - coma
- REFERENCE :
- CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 70,1225,1986
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 14245 mg/kg/5D
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - excitement Skin and Appendages - sweating
- REFERENCE :
- CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 70,1449,1986
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 23125 mg/kg/5D-I
- TOXIC EFFECTS :
- Brain and Coverings - encephalitis Sense Organs and Special Senses (Eye) - visual field changes Behavioral - somnolence (general depressed activity)
- REFERENCE :
- CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 70,1225,1986
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 11655 mg/kg/5D-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - visual field changes Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity)
- REFERENCE :
- CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 70,1449,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1236 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB83-195685
Safety Information
[ Hazard Codes ]:
T
[ Risk Phrases ]:
R25:Toxic if swallowed.
[ Safety Phrases ]:
S45
[ RIDADR ]:
UN 2811 6.1/PG 3
[ HS Code ]:
2934999090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2934999090
[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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