phenylethanolamine

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Names

[ CAS No. ]:
7568-93-6

[ Name ]:
phenylethanolamine

[Synonym ]:
Ethanol, 2- (phenylamino)-
β-Anilinoethanol
a-(Aminomethyl)benzyl alcohol
α-(Aminomethyl)benzyl alcohol
EINECS 231-469-1
N-(β-hydroxy)ethylaniline
phenylethanolamine
Aniline, N-(β-hydroxyethyl)-
b-Hydroxyphenethylamine
Ethanol, 2-(phenylamino)-
β-Hydroxyphenethylamine
2-(phenylamino)ethanol
N-(β-Hydroxyethyl)aniline
β-hydroxy-Phenethylamine
2-Anilinoethanol
Benzenemethanol, α-(aminomethyl)-
dl-β-Phenyl-β-hydroxyethylamine
α-(Aminomethyl)benzenemethanol
β-hydroxy-β-phenyl-Ethylamine
(±)-phenylethanolamine
N-2-hydroxyethylaniline
2-Amino-1-phenylethanol
MFCD00008137

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
286.9±13.0 °C at 760 mmHg

[ Melting Point ]:
56-58 °C(lit.)

[ Molecular Formula ]:
C8H11NO

[ Molecular Weight ]:
137.179

[ Flash Point ]:
151.4±10.5 °C

[ Exact Mass ]:
137.084061

[ PSA ]:
46.25000

[ LogP ]:
0.82

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.600

[ Stability ]:
Stable. Incompatible with oxidizing agents, acids, acid chlorides, acid anhydrides.

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DN5500000
CHEMICAL NAME :
Benzyl alcohol, alpha-(aminomethyl)-
CAS REGISTRY NUMBER :
7568-93-6
BEILSTEIN REFERENCE NO. :
0971222
LAST UPDATED :
199701
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C8-H11-N-O
MOLECULAR WEIGHT :
137.20
WISWESSER LINE NOTATION :
Z1YQR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
686 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 47,96,1934
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1100 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - sympathomimetic
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 153,161,1930
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
23 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 47,96,1934
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948 Volume(issue)/page/year: -,73,1948 *** REVIEWS *** TOXICOLOGY REVIEW CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924- Volume(issue)/page/year: 9,389,1931

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DN5500000

Synthetic Route

Precursor & DownStream

Precursor

  • Styrene oxide
  • (+/-)-2-ACETOXYPROPIONICACID
  • 2-(2-hydroxy-2-phenyl-ethyl)-isoindole-1,3-dione
  • 5-Phenyloxazolidin-2-one
  • Mandelonitrile
  • 2-Amino-1-phenylethanone hydrochloride
  • (+/-)-1-[1-(tert-butylperoxy)-2-nitroethyl]benzene
  • 2-Amino-1-phenylethanone

DownStream

  • N-3,4-DIMETHOXY BENZYL-2-HYDROXYL-2-PHENYL ETHYL AMINE
  • ethyl N-(2-hydroxy-2-phenylethyl)carbamate
  • (S)-2-Benzylamino-1-phenyl-ethanol
  • 2-Thiazolidinethione,5-phenyl-
  • Benzeneethanaminium,b-hydroxy-N,N,N-trimethyl-, iodide (1:1)
  • Benzamide,N-(2-oxo-2-phenylethyl)-
  • 2,2-Diphenylethanamine
  • 2,5-Diphenyloxazole
  • aminorex
  • 2-Phenylethanamine

Articles

A quantum dot based electrochemiluminescent immunosensor for the detection of pg level phenylethanolamine A using gold nanoparticles as substrates and electron transfer accelerators.

Analyst 139(17) , 4365-72, (2014)

This study reports the development of an electrochemiluminescent (ECL) immunosensor for ultrasensitive detection of phenylethanolamine A (PA) based on CdSe quantum dots (QDs) and gold nanoparticles (G...

Development and validation of a sensitive method for simultaneous determination of eight β₂-agonists in pork by ultrasonic-assisted extraction and liquid chromatography/tandem mass spectrometry.

J. Chromatogr. Sci. 53(1) , 104-11, (2014)

A simple and sensitive ultrasonic-assisted extraction coupled with liquid chromatography-tandem quadrupole mass spectrometry was developed for the simultaneous determination of eight β2-agonists (i.e....

Simultaneous determination of plasma phenethylamine, phenylethanolamine, tyramine and octopamine by high-performance liquid chromatography using derivatization with fluorescamine.

J. Chromatogr. A. 427(2) , 320-5, (1988)


More Articles


Related Compounds

  • phenylethanolamine
  • Phenylethanolamine A
  • N-Phenylethanolamine
  • N-Phenylethanolamine
  • (±)-phenylethanolamine
  • (±)-phenylethanolamine
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 2-{4-oxo-3H,4H-thieno[3,2-d]pyrimidin-3-yl}ethyl methanesulfonate
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • 3,9-Dioxabicyclo[3.3.1]nonane-2,4-dione
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine