4-(4-amino-3-fluorophenoxy)-N-methylpicolinamide

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Names

[ CAS No. ]:
757251-39-1

[ Name ]:
4-(4-amino-3-fluorophenoxy)-N-methylpicolinamide

[Synonym ]:
4-(4-amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide
4-(4-Amino-3-fluorophenoxy)-N-methyl-2-pyridinecarboxamide
2-Pyridinecarboxamide, 4-(4-amino-3-fluorophenoxy)-N-methyl-

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
459.8±45.0 °C at 760 mmHg

[ Melting Point ]:
143 °C

[ Molecular Formula ]:
C13H12FN3O2

[ Molecular Weight ]:
261.252

[ Flash Point ]:
231.9±28.7 °C

[ Exact Mass ]:
261.091370

[ PSA ]:
77.24000

[ LogP ]:
0.62

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.602

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Amino-3-fluorophenol
  • N-Methyl-4-chloropyridine-2-carboxamide
  • 4-(cyclohexylideneamino)-3-fluorophenol
  • 3-Fluoro-4-nitrophenol
  • 4-Chlorpyridin-2-carbonylchlorid

DownStream

  • Regorafenib (Hydrochloride)
  • Regorafenib (BAY 73-4506)
  • DCC-2036 (Rebastinib)

Related Compounds

  • 4-(4-Acetamido-3-fluorophenoxy)-N-methylpicolinamide
  • 4-(4-Amino-3-fluorophenoxy)-pyridine-2-carboxylic acid amide
  • Regorafenib (BAY 73-4506)
  • 4-(4-amino-phenylmercapto)-3-n-butylamino-5-n-butylsulfamoylbenzoic acid
  • 4-((4-amino-3-chlorophenyl)thio)-N,N-dimethylbenzamide
  • 4-(4-amino-3-chlorophenoxy)-6-(3-methoxyprop-1-yn-1-yl)-N-methylpyrimidine-5-amine
  • N-[2,4-Bis(dimethylamino)pyrimidin-5-YL]-2-chloro-4-fluorobenzamide
  • N-(2-((2,4-bis(dimethylamino)pyrimidin-5-yl)amino)-2-oxoethyl)benzamide
  • 1-(2,4-Bis(dimethylamino)pyrimidin-5-yl)-3-(2-methoxyphenyl)urea
  • 2-((6-(1H-pyrazol-1-yl)pyridazin-3-yl)oxy)-N-(2,4-bis(dimethylamino)pyrimidin-5-yl)acetamide
  • 2-(5-Bromo-2-methoxyphenyl)propan-1-amine
  • 2-[(4-Chlorophenyl)sulfanyl]-3-pyridinol
  • 4-((6-Chloropyridazin-3-yl)methyl)piperazine-2-carboxylic acid
  • 1-(2-Chlorophenyl)-3-(4-(dimethylamino)-2-(pyrrolidin-1-yl)pyrimidin-5-yl)urea
  • N-(4-(dimethylamino)-2-morpholinopyrimidin-5-yl)isobutyramide
  • 1-(4-(Dimethylamino)-2-morpholinopyrimidin-5-yl)-3-(2-ethylphenyl)urea
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