4-(4-amino-3-fluorophenoxy)-N-methylpicolinamide

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Names

[ CAS No. ]:
757251-39-1

[ Name ]:
4-(4-amino-3-fluorophenoxy)-N-methylpicolinamide

[Synonym ]:
4-(4-amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide
4-(4-Amino-3-fluorophenoxy)-N-methyl-2-pyridinecarboxamide
2-Pyridinecarboxamide, 4-(4-amino-3-fluorophenoxy)-N-methyl-

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
459.8±45.0 °C at 760 mmHg

[ Melting Point ]:
143 °C

[ Molecular Formula ]:
C13H12FN3O2

[ Molecular Weight ]:
261.252

[ Flash Point ]:
231.9±28.7 °C

[ Exact Mass ]:
261.091370

[ PSA ]:
77.24000

[ LogP ]:
0.62

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.602

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Amino-3-fluorophenol
  • N-Methyl-4-chloropyridine-2-carboxamide
  • 4-(cyclohexylideneamino)-3-fluorophenol
  • 3-Fluoro-4-nitrophenol
  • 4-Chlorpyridin-2-carbonylchlorid

DownStream

  • Regorafenib (Hydrochloride)
  • Regorafenib (BAY 73-4506)
  • DCC-2036 (Rebastinib)

Related Compounds

  • 4-(4-Acetamido-3-fluorophenoxy)-N-methylpicolinamide
  • 4-(4-Amino-3-fluorophenoxy)-pyridine-2-carboxylic acid amide
  • Regorafenib (BAY 73-4506)
  • 4-(4-amino-phenylmercapto)-3-n-butylamino-5-n-butylsulfamoylbenzoic acid
  • 4-((4-amino-3-chlorophenyl)thio)-N,N-dimethylbenzamide
  • 4-(4-amino-3-chlorophenoxy)-6-(3-methoxyprop-1-yn-1-yl)-N-methylpyrimidine-5-amine
  • methyl N-{3-[1-(2-methylphenyl)-1H-pyrazol-4-yl]propyl}carbamate
  • Methyl 1-{1-aminospiro[2.5]octan-6-yl}piperidine-4-carboxylate
  • 4-Chloro-5-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)pyrimidine
  • (2-Chloro-6-methylpyridin-3-yl)methanesulfonyl chloride
  • Cyclopenta[3,4]cyclobut[1,2-d]azepine-3(2H)-carboxylic acid, decahydro-6-hydroxy-, 1,1-dimethylethyl ester, (5aR,5bR,6R,8aR,8bR)-rel-
  • 9,12-Octadecadienoic acid (9Z,12Z)-, 2-(acetylamino)-4-(5-amino-3,4-dihydro-2,2-dimethyl-4-oxo-2H-1-benzopyran-6-yl)-4-oxobutyl ester
  • 1,2-Benzenedicarboxylic acid, 1,2-bis[2-[(2-methyl-1-oxo-2-propen-1-yl)oxy]-1-[[(2-methyl-1-oxo-2-propen-1-yl)oxy]methyl]ethyl] ester
  • Carbamic acid, [(1R)-1-[(4-chlorophenyl)methyl]-2-[4-[2-(1-hydroxyethyl)phenyl]-1-piperidinyl]-2-oxoethyl]-, 1,1-dimethylethyl ester
  • Poly[oxy(1-oxo-1,6-hexanediyl)], I+/--hydro-I-hydroxy-, ester with 2,2a(2)-[oxybis(methylene)]bis[2-(hydroxymethyl)-1,3-propanediol] (6:1)
  • 4-O-[4-O-(1,4-Dioxopentyl)-2,3,6-tris-O-(phenylmethyl)-I(2)-D-galactopyranosyl]-2,3,6-tris-O-(phenylmethyl)-D-glucopyranosyl fluoride
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