Enalapril

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Names

[ CAS No. ]:
75847-73-3

[ Name ]:
Enalapril

[Synonym ]:
Enacard
[3H]-Eletriptan
N-[(S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-L-proline
Eletriptan [INN:BAN]
Acesistem
Eletriptan
Lotrial
EINECS 278-375-7
Naprilene
(R)-5-(2-phenylsulphonylethyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole
L-Proline, N-((1S)-1-(ethoxycarbonyl)-3-phenylpropyl)-L-alanyl-
Enalapril
1-[N-[(S)-1-Carboxy-3-phenylpropyl]-1-alanyl]-L-proline 1'-Ethyl Ester
enalaprila
MFCD00865774
N-{(1S)-1-[(ethyloxy)carbonyl]-3-phenylpropyl}-L-alanyl-L-proline
Reniten
N-[(2S)-1-Ethoxy-1-oxo-4-phenyl-2-butanyl]alanyl-L-proline
Eletriptan (INN)
Enap
Renitec
N-[1-(S)-(ethoxycarbonyl)-3-phenylpropyl]alanylproline
3-(N-methyl-2(R)-pyrrolidinylmethyl)-5-(2-phenylsulphonylethyl)-1H-indole
Hipoartel
Amprace
Relpax
olivin
Xanef
N-[(2S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-L-proline
eletriptanum
L-Proline, N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]alanyl-
Enapren
N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-L-proline
Enaloc
Renivace
Glioten
L-Proline, N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-
N-[(2S)-1-Ethoxy-1-oxo-4-phenyl-2-butanyl]-L-alanyl-L-proline
Pres
Innovace
(R)-3-((1-methylpyrrolidin-2-yl)methyl)-5-(2-(phenylsulfonyl)ethyl)-1H-indole

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
582.3±50.0 °C at 760 mmHg

[ Melting Point ]:
143-144.5ºC

[ Molecular Formula ]:
C20H28N2O5

[ Molecular Weight ]:
376.447

[ Flash Point ]:
306.0±30.1 °C

[ Exact Mass ]:
376.199829

[ PSA ]:
170.54000

[ LogP ]:
2.43

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.550

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H317-H361

[ Precautionary Statements ]:
P280

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
TW3665500

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • N-[(S)-1-Ethoxycarbonyl-3-phenylpropyl]-L-alanine
  • Proline
  • H-Ala-Pro-OH
  • ethyl 2-oxo-4-phenylbut-3-enoate
  • N-[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-L-proline Benzylester
  • Ethyl 2-oxo-4-phenylbutanoate
  • Enalapril tert-Butyl Ester
  • N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine acid chloride

DownStream

  • Enalapril maleate
  • Enalaprilat
  • ethyl (2S)-2-[(3S,8aS)-3-methyl-1,4-dioxo-6,7,8,8a-tetrahydro-3H-pyrrolo[1,2-a]pyrazin-2-yl]-4-phenylbutanoate

Articles

Evaluation of a rapid method for the therapeutic drug monitoring of aliskiren, enalapril and its active metabolite in plasma and urine by UHPLC-MS/MS.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 980 , 79-87, (2015)

Given the increasing popularity of aliskiren, particularly in combination with angiotensin converting enzyme inhibitor (e.g. enalapril), it is important to determine whether its use in combination wit...

Mineralocorticoid receptor blockade improves coronary microvascular function in individuals with type 2 diabetes.

Diabetes 64(1) , 236-42, (2015)

Reduced coronary flow reserve (CFR), an indicator of coronary microvascular dysfunction, is seen in type 2 diabetes mellitus (T2DM) and predicts cardiac mortality. Since aldosterone plays a key role i...

Critical blood pressure threshold dependence of hypertensive injury and repair in a malignant nephrosclerosis model.

Hypertension 64(4) , 801-7, (2014)

Most patients with essential hypertension do not exhibit substantial renal damage. Renal autoregulation by preventing glomerular transmission of systemic pressures has been postulated to mediate this ...


More Articles

Related Compounds

  • ENALAPRIL
  • Enalapril
  • enalapril
  • Enalaprilat
  • Enalapril DKP
  • Enalapril / HCTZ
  • 1h-Pyrrolo[2,3-c]pyridine-5-carboxylic acid,1-[(4-fluorophenyl)methyl]-3-[[(tetrahydro-2h-pyran-4-yl)oxy]methyl]-
  • 1h-Pyrrolo[2,3-c]pyridine-5-carboxylic acid,1-[(4-fluorophenyl)methyl]-3-(methoxymethyl)-,methyl ester
  • 2-(2-Fluoro-5-methylphenyl)acetaldehyde
  • (4-Difluoromethoxyphenyl)-acetaldehyde
  • N-{2-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)oxy]ethyl}acetamide
  • 1-(4-aminophenyl)pyrimidin-2(1H)-one
  • 4-Hydroxymethyl 1-(4-iodophenyl)imidazole
  • 4-Aminomethyl 1-(4-iodophenyl)imidazole
  • ethyl N-[(2H-1,3-benzodioxol-5-yl)carbamothioyl]carbamate
  • tert-butyl (3R,4S)-3,4-bis(2-hydroxyethyl)pyrrolidine-1-carboxylate
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