Enalapril
Enalapril structure
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Common Name | Enalapril | ||
|---|---|---|---|---|
| CAS Number | 75847-73-3 | Molecular Weight | 376.447 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 582.3±50.0 °C at 760 mmHg | |
| Molecular Formula | C20H28N2O5 | Melting Point | 143-144.5ºC | |
| MSDS | USA | Flash Point | 306.0±30.1 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
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Evaluation of a rapid method for the therapeutic drug monitoring of aliskiren, enalapril and its active metabolite in plasma and urine by UHPLC-MS/MS.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 980 , 79-87, (2015) Given the increasing popularity of aliskiren, particularly in combination with angiotensin converting enzyme inhibitor (e.g. enalapril), it is important to determine whether its use in combination with these agents is associated with potentially life threaten... |
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Mineralocorticoid receptor blockade improves coronary microvascular function in individuals with type 2 diabetes.
Diabetes 64(1) , 236-42, (2015) Reduced coronary flow reserve (CFR), an indicator of coronary microvascular dysfunction, is seen in type 2 diabetes mellitus (T2DM) and predicts cardiac mortality. Since aldosterone plays a key role in vascular injury, the aim of this study was to determine w... |
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Critical blood pressure threshold dependence of hypertensive injury and repair in a malignant nephrosclerosis model.
Hypertension 64(4) , 801-7, (2014) Most patients with essential hypertension do not exhibit substantial renal damage. Renal autoregulation by preventing glomerular transmission of systemic pressures has been postulated to mediate this resistance. Conversely, malignant nephrosclerosis (MN) has ... |
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Novel Bradykinin Analogues Modified in the N-Terminal Part of the Molecule with a Variety of Acyl Substituents.
Int. J. Pept. Res. Ther. 18(2) , 117-124, (2012) In the current work we present some pharmacological characteristics of ten new analogues of bradykinin (Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg) modified in the N-terminal part of the molecule with a variety of acyl substituents. Of the many acylating agents used... |
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Profibrosing effect of angiotensin converting enzyme inhibitors in human lung fibroblasts.
Lung 193(2) , 199-202, (2015) The objective of this study is to determine the effect of two angiotensin-converting enzyme inhibitors (ACEi) (Enalapril and Captopril), an angiotensin-II receptor inhibitor (Losartan) and a renin inhibitor (Aliskiren) on renin, TGF-β1 and collagen expression... |
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Combination of ACE inhibitor with nicorandil provides further protection in chronic kidney disease.
Am. J. Physiol. Renal Physiol. 307(12) , F1313-22, (2014) An inhibition in the renin-angiotensin system (RAS) is one of the most widely used therapies to treat chronic kidney disease. However, its effect is occasionally not sufficient and additional treatments may be required. Recently, we reported that nicorandil e... |
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The water channel aquaporin-1 contributes to renin cell recruitment during chronic stimulation of renin production.
Am. J. Physiol. Renal Physiol. 307(11) , F1215-26, (2014) Both the processing and release of secretory granules involve water movement across granule membranes. It was hypothesized that the water channel aquaporin (AQP)1 directly contributes to the recruitment of renin-positive cells in the afferent arteriole. AQP1(... |
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Losartan Treatment Protects Retinal Ganglion Cells and Alters Scleral Remodeling in Experimental Glaucoma.
PLoS ONE 10 , e0141137, (2015) To determine if oral losartan treatment decreases the retinal ganglion cell (RGC) death caused by experimental intraocular pressure (IOP) elevation in mice.We produced IOP increase in CD1 mice and performed unilateral optic nerve crush. Mice received oral los... |
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Vasculopathy-associated hyperangiotensinemia mobilizes haematopoietic stem cells/progenitors through endothelial AT₂R and cytoskeletal dysregulation.
Nat. Commun. 6 , 5914, (2015) Patients with organ failure of vascular origin have increased circulating haematopoietic stem cells and progenitors (HSC/P). Plasma levels of angiotensin II (Ang-II), are commonly increased in vasculopathies. Hyperangiotensinemia results in activation of a ve... |
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A chrysin analog exhibited strong inhibitory activities against both PGE2 and NO production.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 305(10) , R1133-40, (2013) A number of 8-substituted chrysin analogs have been prepared and evaluated for their inhibitory activities of cyclooxygenase-2 catalyzed prostaglandin E(2) and iNOS-mediated NO production. Analogs were prepared via Suzuki-Miyaura C-C cross coupling reaction o... |