Ethyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate

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Names

[ CAS No. ]:
7598-91-6

[ Name ]:
Ethyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate

[Synonym ]:
MFCD00044575
ethyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate
EINECS 231-507-7

Chemical & Physical Properties

[ Density]:
1.282 g/cm3

[ Boiling Point ]:
406.7ºC at 760 mmHg

[ Melting Point ]:
205-208ºC(lit.)

[ Molecular Formula ]:
C12H13NO3

[ Molecular Weight ]:
219.23700

[ Flash Point ]:
199.7ºC

[ Exact Mass ]:
219.09000

[ PSA ]:
62.32000

[ LogP ]:
2.35860

[ Index of Refraction ]:
1.5270 (estimate)

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
F+

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3.0

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • ethyl 3-aminocrotonate
  • 1,4-Benzoquinone
  • Ethyl (2Z)-3-amino-2-butenoate

DownStream

  • PD 102807
  • 5-Hydroxy-2-methyl-1H-indole-3-carboxylic acid
  • 6-BROMO-5-HYDROXY-2-METHYL-1H-INDOLE-3-ARBOXYLIC ACID, ETHYL ESTER
  • 2-Methyl-1H-indol-5-ol
  • 5-Methoxy-2-methyl-1H-indole-3-carboxylic acid
  • 1H-Indole-3-carboxylicacid, 4,5-dihydro-2-methyl-4,5-dioxo-, ethyl ester
  • ethyl 5-methoxy-1,2-dimethylindole-3-carboxylate

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors.

J. Med. Chem. 51 , 4351, (2008)

1-Aroylindoline, 1-aroyl-1,2,3,4-tetrahydroquinoline, and 1-aroylindole derivatives were synthesized and evaluated for anticancer activity. The 4-amino and 4-hydroxy-1-aroylindoles 26 and 27 with IC 5...

Synthesis and pharmacology of benzoxazines as highly selective antagonists at M(4) muscarinic receptors.

J. Med. Chem. 45 , 3094, (2002)

Previously, we reported on PD 102807 (41) as being the most selective synthetic M(4) muscarinic antagonist identified to date. Synthesized analogues of 41 showed no improvement in affinity and selecti...

5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity.

J. Med. Chem. 52 , 3855, (2009)

Obesity is a major risk factor in the development of conditions such as hypertension, hyperglycemia, dyslipidemia, coronary artery disease, and cancer. Several pieces of evidence across different spec...


More Articles

Related Compounds

  • Methyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate
  • Methyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate
  • Methyl 1-ethyl-5-hydroxy-2-methyl-1H-indole-3-carboxylate
  • ethyl 5-hydroxy-2-methyl-1H-benzo[g]indole-3-carboxylate
  • ethyl 1-benzyl-5-hydroxy-2-methyl-1H-indole-3-carboxylate
  • ETHYL 1-CYCLOHEXYL-5-HYDROXY-2-METHYL-1H-INDOLE-3-CARBOXYLATE