(+/-)-Camphor

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Names

[ CAS No. ]:
76-22-2

[ Name ]:
(+/-)-Camphor

[Synonym ]:
(+)-bornan-2-one
Bicyclo(2.2.1)heptan-2-one, 1,7,7-trimethyl-
camphanone
3-Fluor-2,2-dimethyl-bicyclo<2.2.1>heptan
(1S,4S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one
1,7,7-Trimethylbicyclo[2.2.1]-2-heptanone
2-Kamfanon
D-CAMPHOR
(±)-bornan-2-one
2-Oxo-bornan
2-Bornanone,2-Camphanone,D-Camphor
Radian B
lphanon
DL-2-Bornanone
D-(+)-Camphor
MFCD00676613
Alphanon
L(-)-Camphor
1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one
DL-Camphor
Camphen-hydrofluorid
(1RS,4RS)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
Caladryl
(-)-Camphor
2-Keto-1,7,7-trimethylnolcamphane
Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-
(−)-Camphor,(1S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one
2-CAMPHOR
EINECS 200-945-0
(±)-Camphor
2-Camphonone
Dehydrocamphor
Camphor
(+)-CaMphor
(1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
2-Bornanone,2-Camphanone
D(+)-Camphor
2-Bornanone 2-Camphanone
Kampfer
(+)-Camphor,(1R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one
camphre
(1S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
207.4±0.0 °C at 760 mmHg

[ Melting Point ]:
175-177 °C(lit.)

[ Molecular Formula ]:
C₁₀H₁₆O

[ Molecular Weight ]:
152.233

[ Flash Point ]:
64.4±0.0 °C

[ Exact Mass ]:
152.120117

[ PSA ]:
17.07000

[ LogP ]:
2.13

[ Vapour density ]:
5.2 (vs air)

[ Vapour Pressure ]:
0.2±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.485

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents, metallic salts, combustible materials, organics.

[ Water Solubility ]:
0.12 g/100 mL (25 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EX1225000

CHEMICAL NAME :: Camphor

CAS REGISTRY NUMBER :: 76-22-2

BEILSTEIN REFERENCE NO. :: 3196099

LAST UPDATED :: 199712

DATA ITEMS CITED :: 50

MOLECULAR FORMULA :: C10-H16-O

MOLECULAR WEIGHT :: 152.26

WISWESSER LINE NOTATION :: L55 A CVTJ A1 A1 B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - infant

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 51 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 29 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1310 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/m3/3H

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Behavioral - rigidity (including catalepsy)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Behavioral - excitement

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Behavioral - rigidity (including catalepsy)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 240 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 210 mg/m3/3H/7W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - emphysema

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 33 mg/m3/3H/7W-I

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Cardiac - other changes Lungs, Thorax, or Respiration - emphysema

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 224,157,1989 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-STEL 19 mg/m3 (3 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 12 mg/m3 (2 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO 63132) V.3- 1969- Volume(issue)/page/year: 12,27,1974 TOXICOLOGY REVIEW NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB293-503 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 2 ppm (12 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,37,1971 OSHA PEL (Gen Indu):8H TWA 2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 2 ppm (12 mg/m3);STEL 3 ppm (18 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 2 ppm (13 mg/m3) JAN 1993 OEL-BELGIUM:TWA 2 ppm (12 mg/m3);STEL 3 ppm (19 mg/m3) JAN 1993 OEL-DENMARK:TWA 2 ppm (12 mg/m3) JAN 1993 OEL-FINLAND:TWA 0.3 ppm (2 mg/m3);STEL 0.9 ppm (6 mg/m3) JAN 1993 OEL-FRANCE:TWA 2 ppm (12 mg/m3) JAN 1993 OEL-GERMANY:TWA 2 ppm (13 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 2 ppm (12 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 2 ppm (12 mg/m3) JAN 1993 OEL-RUSSIA:STEL 3 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 2 ppm (13 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 2 ppm (12 mg/m3);STEL 3 ppm (18 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CAMPHOR, synthetic-air:10H TWA 2 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 15800 No. of Facilities: 8356 (estimated) No. of Industries: 68 No. of Occupations: 63 No. of Employees: 95578 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1190 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 427 (estimated) No. of Female Employees: 176 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 15800 No. of Facilities: 9166 (estimated) No. of Industries: 101 No. of Occupations: 87 No. of Employees: 153554 (estimated) No. of Female Employees: 53187 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H228-H302 + H332-H371

[ Precautionary Statements ]:
P210-P260-P301 + P312 + P330-P370 + P378

[ Target Organs ]:
Lungs

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
F:Flammable

[ Risk Phrases ]:
R11;R36/37/38

[ Safety Phrases ]:
S16-S26-S37/39

[ RIDADR ]:
UN 2717 4.1/PG 3

[ WGK Germany ]:
1

[ RTECS ]:
EX1225000

[ Packaging Group ]:
III

[ Hazard Class ]:
4.1

[ HS Code ]:
2914291000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-methylisoborneol
DL-2-Bornanol
enolacetate of camphor
Isoborneol
()-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one oxime
4',7',7'-trimethylspiro[1,3-dithiolane-2,3'-bicyclo[2.2.1]heptane]
d-3-bromocamphor
borneol
thiocamphor

DownStream

exo-(-)-bornylamine
(R)-(+)-Bornylamine
1,2,3,5-tetramethylbenzene
α-campholenaldehyde
DL-2-Bornanol
borneol
(-)-Borneol
(+)-Borneol
Isoborneol

Customs

[ HS Code ]: 2914291000

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