(+/-)-Camphor

Modify Date: 2024-01-02 14:01:48

(+/-)-Camphor Structure
(+/-)-Camphor structure
 Common Name (+/-)-Camphor
CAS Number 76-22-2 Molecular Weight 152.233
Density 1.0±0.1 g/cm3 Boiling Point 207.4±0.0 °C at 760 mmHg
Molecular Formula C10H16O Melting Point 175-177 °C(lit.)
MSDS Chinese USA Flash Point 64.4±0.0 °C
Symbol GHS02 GHS07 GHS08
GHS02, GHS07, GHS08		 Signal Word Warning

 Use of (+/-)-Camphor


Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities[1]. Camphor is a TRPV3 agonist[2].

 Names

Name camphor
Synonym More Synonyms

 (+/-)-Camphor Biological Activity

Description Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities[1]. Camphor is a TRPV3 agonist[2].
Related Catalog
Target

TRPV3[2]

In Vitro Camphor induces fibroblast proliferation through the PI3K/AKT and ERK signaling pathways. The MTT assay results show that 32.5, 65, 130, and 260 μM Camphor increase fibroblast viability to 108.9±6.6%, 118.6±2.8%, 127.7±4.2%, and 131.6±7.2%, respectively, compared to 0 μM Camphor treatment. Camphor treatment for 24 h increases the generation of ROS by up to 17.97% compared to 5.04% in the no-treatment control[3].
Cell Assay Primary dermal fibroblast (2×104 cells/mL) cells are plated in 96-well plates in 200μL of medium containing 10% FBS. After 24 h, the cells are treated with various concentrations of chamomile hydrosol or Camphor (0-260 μM). After treatment, 20 μL of MTT solution (5mg/mL) is added to each well, followed by incubation in a humidified environment for 3-4 h. The supernatant is removed and 150 μL of DMSO is added. Cell viability is determined from the absorbance at 570 nm, measured using a Sunrise microplate reader[3].
References

[1]. Chen W, et al. Camphor--a fumigant during the Black Death and a coveted fragrant wood in ancient Egypt and Babylon--a review. Molecules. 2013 May 10;18(5):5434-54.

[2]. Billen B, et al. Different ligands of the TRPV3 cation channel cause distinct conformational changes as revealedby intrinsic tryptophan fluorescence quenching. J Biol Chem. 2015 May 15;290(20):12964-74.

[3]. Tran TA, et al. Camphor Induces Proliferative and Anti-senescence Activities in Human Primary Dermal Fibroblasts and Inhibits UV-Induced Wrinkle Formation in Mouse Skin. Phytother Res. 2015 Dec;29(12):1917-25.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 207.4±0.0 °C at 760 mmHg
Melting Point 175-177 °C(lit.)
Molecular Formula C10H16O
Molecular Weight 152.233
Flash Point 64.4±0.0 °C
Exact Mass 152.120117
PSA 17.07000
LogP 2.13
Vapour density 5.2 (vs air)
Vapour Pressure 0.2±0.4 mmHg at 25°C
Index of Refraction 1.485
Stability Stable. Combustible. Incompatible with strong oxidizing agents, metallic salts, combustible materials, organics.
Water Solubility 0.12 g/100 mL (25 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EX1225000
CHEMICAL NAME :
Camphor
CAS REGISTRY NUMBER :
76-22-2
BEILSTEIN REFERENCE NO. :
3196099
LAST UPDATED :
199712
DATA ITEMS CITED :
50
MOLECULAR FORMULA :
C10-H16-O
MOLECULAR WEIGHT :
152.26
WISWESSER LINE NOTATION :
L55 A CVTJ A1 A1 B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - infant
DOSE/DURATION :
70 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
51 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
29 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
900 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
70 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1310 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 mg/m3/3H
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Behavioral - rigidity (including catalepsy)
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Behavioral - rigidity (including catalepsy)
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
240 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
210 mg/m3/3H/7W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - emphysema
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
33 mg/m3/3H/7W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Cardiac - other changes Lungs, Thorax, or Respiration - emphysema

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 224,157,1989 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-STEL 19 mg/m3 (3 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 12 mg/m3 (2 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO 63132) V.3- 1969- Volume(issue)/page/year: 12,27,1974 TOXICOLOGY REVIEW NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB293-503 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 2 ppm (12 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,37,1971 OSHA PEL (Gen Indu):8H TWA 2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 2 ppm (12 mg/m3);STEL 3 ppm (18 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 2 ppm (13 mg/m3) JAN 1993 OEL-BELGIUM:TWA 2 ppm (12 mg/m3);STEL 3 ppm (19 mg/m3) JAN 1993 OEL-DENMARK:TWA 2 ppm (12 mg/m3) JAN 1993 OEL-FINLAND:TWA 0.3 ppm (2 mg/m3);STEL 0.9 ppm (6 mg/m3) JAN 1993 OEL-FRANCE:TWA 2 ppm (12 mg/m3) JAN 1993 OEL-GERMANY:TWA 2 ppm (13 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 2 ppm (12 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 2 ppm (12 mg/m3) JAN 1993 OEL-RUSSIA:STEL 3 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 2 ppm (13 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 2 ppm (12 mg/m3);STEL 3 ppm (18 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CAMPHOR, synthetic-air:10H TWA 2 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 15800 No. of Facilities: 8356 (estimated) No. of Industries: 68 No. of Occupations: 63 No. of Employees: 95578 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1190 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 427 (estimated) No. of Female Employees: 176 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 15800 No. of Facilities: 9166 (estimated) No. of Industries: 101 No. of Occupations: 87 No. of Employees: 153554 (estimated) No. of Female Employees: 53187 (estimated)

 Safety Information

Symbol GHS02 GHS07 GHS08
GHS02, GHS07, GHS08
Signal Word Warning
Hazard Statements H228-H302 + H332-H371
Precautionary Statements P210-P260-P301 + P312 + P330-P370 + P378
Target Organs Lungs
Personal Protective Equipment dust mask type N95 (US);Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes F:Flammable
Risk Phrases R11;R36/37/38
Safety Phrases S16-S26-S37/39
RIDADR UN 2717 4.1/PG 3
WGK Germany 1
RTECS EX1225000
Packaging Group III
Hazard Class 4.1
HS Code 2914291000

 Synthetic Route

 Customs

HS Code 2914291000

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 Synonyms

(+)-bornan-2-one
Bicyclo(2.2.1)heptan-2-one, 1,7,7-trimethyl-
camphanone
3-Fluor-2,2-dimethyl-bicyclo<2.2.1>heptan
(1S,4S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one
1,7,7-Trimethylbicyclo[2.2.1]-2-heptanone
2-Kamfanon
D-CAMPHOR
(±)-bornan-2-one
2-Oxo-bornan
2-Bornanone,2-Camphanone,D-Camphor
Radian B
lphanon
DL-2-Bornanone
D-(+)-Camphor
MFCD00676613
Alphanon
L(-)-Camphor
1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one
DL-Camphor
Camphen-hydrofluorid
(1RS,4RS)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
Caladryl
(-)-Camphor
2-Keto-1,7,7-trimethylnolcamphane
Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-
(−)-Camphor,(1S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one
2-CAMPHOR
EINECS 200-945-0
(±)-Camphor
2-Camphonone
Dehydrocamphor
Camphor
(+)-CaMphor
(1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
2-Bornanone,2-Camphanone
D(+)-Camphor
2-Bornanone 2-Camphanone
Kampfer
(+)-Camphor,(1R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one
camphre
(1S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one
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