(+/-)-Camphor

Modify Date: 2025-08-23 08:26:37

(+/-)-Camphor structure	Common Name	(+/-)-Camphor
	CAS Number	76-22-2	Molecular Weight	152.233
	Density	1.0±0.1 g/cm3	Boiling Point	207.4±0.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₆O	Melting Point	175-177 °C(lit.)
	MSDS	Chinese USA	Flash Point	64.4±0.0 °C
	Symbol	GHS02, GHS07, GHS08	Signal Word	Warning

Use of (+/-)-Camphor

Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities[1]. Camphor is a TRPV3 agonist[2].

Name	camphor
Synonym	More Synonyms

Description	Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities[1]. Camphor is a TRPV3 agonist[2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Natural Products >> Terpenoids and Glycosides Research Areas >> Cancer Research Areas >> Inflammation/Immunology Research Areas >> Infection
Target	TRPV3[2]
In Vitro	Camphor induces fibroblast proliferation through the PI3K/AKT and ERK signaling pathways. The MTT assay results show that 32.5, 65, 130, and 260 μM Camphor increase fibroblast viability to 108.9±6.6%, 118.6±2.8%, 127.7±4.2%, and 131.6±7.2%, respectively, compared to 0 μM Camphor treatment. Camphor treatment for 24 h increases the generation of ROS by up to 17.97% compared to 5.04% in the no-treatment control[3].
Cell Assay	Primary dermal fibroblast (2×104 cells/mL) cells are plated in 96-well plates in 200μL of medium containing 10% FBS. After 24 h, the cells are treated with various concentrations of chamomile hydrosol or Camphor (0-260 μM). After treatment, 20 μL of MTT solution (5mg/mL) is added to each well, followed by incubation in a humidified environment for 3-4 h. The supernatant is removed and 150 μL of DMSO is added. Cell viability is determined from the absorbance at 570 nm, measured using a Sunrise microplate reader[3].
References	[1]. Chen W, et al. Camphor--a fumigant during the Black Death and a coveted fragrant wood in ancient Egypt and Babylon--a review. Molecules. 2013 May 10;18(5):5434-54. [2]. Billen B, et al. Different ligands of the TRPV3 cation channel cause distinct conformational changes as revealedby intrinsic tryptophan fluorescence quenching. J Biol Chem. 2015 May 15;290(20):12964-74. [3]. Tran TA, et al. Camphor Induces Proliferative and Anti-senescence Activities in Human Primary Dermal Fibroblasts and Inhibits UV-Induced Wrinkle Formation in Mouse Skin. Phytother Res. 2015 Dec;29(12):1917-25.

Density	1.0±0.1 g/cm3
Boiling Point	207.4±0.0 °C at 760 mmHg
Melting Point	175-177 °C(lit.)
Molecular Formula	C₁₀H₁₆O
Molecular Weight	152.233
Flash Point	64.4±0.0 °C
Exact Mass	152.120117
PSA	17.07000
LogP	2.13
Vapour density	5.2 (vs air)
Vapour Pressure	0.2±0.4 mmHg at 25°C
Index of Refraction	1.485
Stability	Stable. Combustible. Incompatible with strong oxidizing agents, metallic salts, combustible materials, organics.
Water Solubility	0.12 g/100 mL (25 ºC)

(+/-)-Camphor MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EX1225000

CHEMICAL NAME :: Camphor

CAS REGISTRY NUMBER :: 76-22-2

BEILSTEIN REFERENCE NO. :: 3196099

LAST UPDATED :: 199712

DATA ITEMS CITED :: 50

MOLECULAR FORMULA :: C10-H16-O

MOLECULAR WEIGHT :: 152.26

WISWESSER LINE NOTATION :: L55 A CVTJ A1 A1 B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - infant

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 51 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 29 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1310 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/m3/3H

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Behavioral - rigidity (including catalepsy)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Behavioral - excitement

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Behavioral - rigidity (including catalepsy)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 240 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 210 mg/m3/3H/7W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - emphysema

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 33 mg/m3/3H/7W-I

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Cardiac - other changes Lungs, Thorax, or Respiration - emphysema

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 224,157,1989 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-STEL 19 mg/m3 (3 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 12 mg/m3 (2 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO 63132) V.3- 1969- Volume(issue)/page/year: 12,27,1974 TOXICOLOGY REVIEW NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB293-503 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 2 ppm (12 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,37,1971 OSHA PEL (Gen Indu):8H TWA 2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 2 ppm (12 mg/m3);STEL 3 ppm (18 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 2 ppm (13 mg/m3) JAN 1993 OEL-BELGIUM:TWA 2 ppm (12 mg/m3);STEL 3 ppm (19 mg/m3) JAN 1993 OEL-DENMARK:TWA 2 ppm (12 mg/m3) JAN 1993 OEL-FINLAND:TWA 0.3 ppm (2 mg/m3);STEL 0.9 ppm (6 mg/m3) JAN 1993 OEL-FRANCE:TWA 2 ppm (12 mg/m3) JAN 1993 OEL-GERMANY:TWA 2 ppm (13 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 2 ppm (12 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 2 ppm (12 mg/m3) JAN 1993 OEL-RUSSIA:STEL 3 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 2 ppm (13 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 2 ppm (12 mg/m3);STEL 3 ppm (18 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CAMPHOR, synthetic-air:10H TWA 2 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 15800 No. of Facilities: 8356 (estimated) No. of Industries: 68 No. of Occupations: 63 No. of Employees: 95578 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1190 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 427 (estimated) No. of Female Employees: 176 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 15800 No. of Facilities: 9166 (estimated) No. of Industries: 101 No. of Occupations: 87 No. of Employees: 153554 (estimated) No. of Female Employees: 53187 (estimated)

Symbol	GHS02, GHS07, GHS08
Signal Word	Warning
Hazard Statements	H228-H302 + H332-H371
Precautionary Statements	P210-P260-P301 + P312 + P330-P370 + P378
Target Organs	Lungs
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	F:Flammable
Risk Phrases	R11;R36/37/38
Safety Phrases	S16-S26-S37/39
RIDADR	UN 2717 4.1/PG 3
WGK Germany	1
RTECS	EX1225000
Packaging Group	III
Hazard Class	4.1
HS Code	2914291000

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HS Code	2914291000

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(+)-bornan-2-one

Bicyclo(2.2.1)heptan-2-one, 1,7,7-trimethyl-

camphanone

3-Fluor-2,2-dimethyl-bicyclo<2.2.1>heptan

(1S,4S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one

1,7,7-Trimethylbicyclo[2.2.1]-2-heptanone

2-Kamfanon

D-CAMPHOR

(±)-bornan-2-one

2-Oxo-bornan

2-Bornanone,2-Camphanone,D-Camphor

Radian B

lphanon

DL-2-Bornanone

D-(+)-Camphor

MFCD00676613

Alphanon

L(-)-Camphor

1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one

DL-Camphor

Camphen-hydrofluorid

(1RS,4RS)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one

Caladryl

(-)-Camphor

2-Keto-1,7,7-trimethylnolcamphane

Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-

(−)-Camphor,(1S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one

2-CAMPHOR

EINECS 200-945-0

(±)-Camphor

2-Camphonone

Dehydrocamphor

Camphor

(+)-CaMphor

(1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one

2-Bornanone,2-Camphanone

D(+)-Camphor

2-Bornanone 2-Camphanone

Kampfer

(+)-Camphor,(1R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one

camphre

(1S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: (+/-)-Camphor
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: (+/-)-Camphor
Price: ￥88.0/100mg
Purity: 98.0%
Delivery: 3 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Camphor
Price: $280.0/20mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Camphor
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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(+/-)-Camphor

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(+/-)-Camphor Biological Activity

Chemical & Physical Properties

MSDS

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CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

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