5-Brom-2-fluorpyridin

Names

[ CAS No. ]:
766-11-0

[ Name ]:
5-Brom-2-fluorpyridin

[Synonym ]:
5-Bromo-2-fluoropyridine
5-Bromo-2-Fluoro Pyridine
2-Fluoro-5-bromopyridine
3-Bromo-6-fluoropyridine
5-Brom-2-fluorpyridin
Pyridine, 5-bromo-2-fluoro-
MFCD01863742

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
178.0±20.0 °C at 760 mmHg

[ Molecular Formula ]:
C₅H₃BrFN

[ Molecular Weight ]:
175.99

[ Flash Point ]:
61.4±21.8 °C

[ Exact Mass ]:
174.943283

[ PSA ]:
12.89000

[ LogP ]:
1.80

[ Vapour Pressure ]:
1.4±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.534

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36/37

[ RIDADR ]:
UN 2810

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

6-Fluoronicotinic acid
5-Bromo-2-nitropyridine

DownStream

3-PyridineMethanol, 5-bromo-2-fluoro-α-Methyl-
2-Fluoro-5-pyridylboronic acid
5-BROMO-2-(CYCLOPROPYLMETHOXY)PYRIDINE
6-Fluoro-3-pyridinol
2-Fluoro-3-formylpyridine
2-Fluoropyridine-5-boronic acid pinacol ester
6-Cyclopropylmethoxypyridine-3-boronic acid pinacol ester
(5-Bromo-2-fluoro-3-pyridinyl)boronic acid
5-Bromo-2-(4-piperidinyloxy)pyridine

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Versatile synthesis of 3,5-disubstituted 2-fluoropyridines and 2-pyridones.

J. Org. Chem. 68(8) , 3352-5, (2003)

5-bromo-2-fluoro-3-pyridylboronic acid (3) was prepared in high yield by ortho-lithiation of 5-bromo-2-fluoropyridine (1), followed by reaction with trimethylborate. Suzuki reaction of 3 with a range ...

Synthesis of two fluoro analogues of the nicotinic acetylcholine receptor agonist UB-165.

J. Org. Chem. 68(6) , 2475-8, (2003)

Two racemic fluoropyridine analogues 4 and 5 of the potent nicotinic agonist UB-165 have been synthesized. Halogenated pyridines 7 and 12 provided the organometallic reagents needed for the Negishi an...

Aromatic fluorine compounds. XI. Replacement of chlorine by fluorine in halopyridines. Finger GC, et al.

J. Org. Chem. 28(6) , 1666-1668, (1963)

5-Brom-2-methyl-8-nitroisochinolinium-p-toluolsulfonat
5-Brom-2,3-dichlorpyridin
5-Brom-2-(4-brombenzyl)-benzoesaeure
5-Brom-2-propyl-phenol
5-Brom-2-(N-methyl-p-toluolsulfonamido)-benzophenon
5-Brom-2,4-dimethyl-resorcin-diacetat
1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid, 6-phenyl-, ethyl ester
Hexadecanoic acid, 3,7,11,15-tetramethyl-, 1,2,3-propanetriyl ester
Cyclopropanecarboxylic acid, 1-[2-bromo-5-(trifluoromethyl)phenyl]-
L-Tryptophan, N-[(1,1-dimethylethoxy)carbonyl]-1-formyl-, anhydride
C,Ca(2)-1,6-Hexanediyl bis[N,Na(2)-3-[3-(triethoxysilyl)propyl]carbamate]
4-[(3,5-Dimethyl[1,1a(2)-biphenyl]-4-yl)imino]-2,5-cyclohexadien-1-one
Poly(oxy-1,2-ethanediyl), I+/--(2-ethylhexyl)-I-[(2-hydroxydecyl)oxy]-
1,5-Dioxaspiro[2.5]octane-6-carboxylic acid, 2,6,7-trimethyl-4-oxo-
N2-[(1,1-Dimethylethoxy)carbonyl]-N-(1,1-dimethylethyl)-L-glutamine
N-[2-(4,5-Dihydro-2-octadecyl-1H-imidazol-1-yl)ethyl]nonadecanamide

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